- cafead Nov 09, 2021 at 10:52: AM
via Novartis has hacked off another piece of its $2.6 billion deal with Xencor, terminating its rights to a CD123xCD3 blood cancer bispecific that had a troubled time in early clinical development.
Xencor granted Novartis ex-U.S. rights to CD123xCD3 candidate vibecotamab and a second bispecific antibody back in 2016. Novartis dumped the other drug candidate, XmAb13676, in 2019, but it stuck by vibecotamab as Xencor battled through a partial clinical hold triggered by two patient deaths that were considered at least possibly related to the bispecific and went on to post phase 1 data.
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Xencor granted Novartis ex-U.S. rights to CD123xCD3 candidate vibecotamab and a second bispecific antibody back in 2016. Novartis dumped the other drug candidate, XmAb13676, in 2019, but it stuck by vibecotamab as Xencor battled through a partial clinical hold triggered by two patient deaths that were considered at least possibly related to the bispecific and went on to post phase 1 data.
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