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Near-Term Patent Expirations

anonymous

Guest
Looking forward to next year's patent expirations:

$ 1.2B Alimta (Jan 2017)
$ 0.4B Effient (Apr 2017)
$ 0.5B Strattera (May 2017)
$ 1.3B Cialis (Nov 2017)

$ 3.4B Total​

Will the new launches (line extensions) make up for, or surpass, this revenue loss?

If not, then what?

Serious comments only, please.
 






New launches? There are none.
Line extensions? Useless and unenforceable thanks to the AIA. IPR proceeding before the PTAB will invalidate whatever patents that exist for NILEX. Get ready to see thousands reallocated.
 




Oh we have HR's diversity programs and we have Six Sigma.

Management bubble gum.

Seriously, I have posted this here before, and I promise, this is the last time:

Take a company with a novel device, already approved for some applications, by FDA, then adapt it to bypass the usual syringe technology (which is a horror for many reasons). There are many companies that do this (or are trying to). We could take multiple generics, adapt to inhalation technology (WHY NOT... look at electronic cigarettes, saving millions of lives), get fast tracked NDAs (proven for the most complicated molecules. One company is Mannkind. There are others. All I have to say about this, this is the upper mgmt IQ test.
 




Oh we have HR's diversity programs and we have Six Sigma.

Management bubble gum.

Seriously, I have posted this here before, and I promise, this is the last time:

Take a company with a novel device, already approved for some applications, by FDA, then adapt it to bypass the usual syringe technology (which is a horror for many reasons). There are many companies that do this (or are trying to). We could take multiple generics, adapt to inhalation technology (WHY NOT... look at electronic cigarettes, saving millions of lives), get fast tracked NDAs (proven for the most complicated molecules. One company is Mannkind. There are others. All I have to say about this, this is the upper mgmt IQ test.

God, you are an idiot.

MannKind (NASDAQ:MNKD) investors received news today that the founder, Executive Chairman, and Board of Directors member, Al Mann, has resigned as a company executive and as a board member. MannKind also announced that Kent Kresa will be promoted to Chairman of the Board of Directors.

News of the event was muted as far as the stock is concerned, but investors need to consider what these most recent events mean. With Al Mann on the sidelines in the boardroom, speculation will likely turn a bit wild. Was there contention on the board about the direction of the company? Did the board request such a move? Is there dissension on the board? There is certainly any number of possibilities.

Ever since the erosion of the partnership with Sanofi and the return of marketing rights of Afrezza to MannKind, the stock has been muddled in a cloud of uncertainty. Even a subsequent deal announced regarding MannKind technology seems to have more smoke and mirrors than a carnival fun house. After MannKind stating no connection with Receptor Life Sciences, we learn that a key MannKind employee was hired by the secretive group about 5 months prior to the consummation of a deal that brought no up-front cash to MannKind.

Reuters recently indicated that MannKind management had possibly engaged the services of an investment bank and that an outright sale of the companywas a possibility. With rumors swirling and speculation running wild, it may well be that Al Mann simply decided to separate himself from the story.
 




Here's the thing: this technology either delivers API to the target, avoiding first-pass metabolism, or it does not. If it does not, stay away. If it does, pick it up at fire sale prices, and go to town saving the pipeline. Most drugs die because of PK issues; if the technospheres work as claimed, that's something of value.:cool:
 




Looking forward to next year's patent expirations:

$ 1.2B Alimta (Jan 2017)
$ 0.4B Effient (Apr 2017)
$ 0.5B Strattera (May 2017)
$ 1.3B Cialis (Nov 2017)

$ 3.4B Total​

Will the new launches (line extensions) make up for, or surpass, this revenue loss?

If not, then what?

Serious comments only, please.
Between 2010 and 2015 Lilly increased the price of Humulin R U-500 by 325%. If you don't have anything significant in the pipeline, I guess that's how you make your money.
 




Between 2010 and 2015 Lilly increased the price of Humulin R U-500 by 325%. If you don't have anything significant in the pipeline, I guess that's how you make your money.
So true! While sending thousands of scientists to the unemployment line...to achieve "cost savings"...passed on to layers of useless management...who plan more mass layoffs of scientists. What a cycle!
 




Here's the thing: this technology either delivers API to the target, avoiding first-pass metabolism, or it does not. If it does not, stay away. If it does, pick it up at fire sale prices, and go to town saving the pipeline. Most drugs die because of PK issues; if the technospheres work as claimed, that's something of value.:cool:


Thank you. Someone with an IQ over 150 around here.

Thanks to the mafia (Margaret Hamburg, her hedge fund hubby, and Martin Shrkeli), technospheres are the most studied drug ever with respect to efficacy and safety.

Some people just don't get it.
 




Between 2010 and 2015 Lilly increased the price of Humulin R U-500 by 325%. If you don't have anything significant in the pipeline, I guess that's how you make your money.

The truth hurts..............................................

Insulin has been around for almost a century. The World Health Organization considers it an essential medicine, which means it should be available “at a price the individual and the community can afford.” So why is this product increasingly too expensive for many Americans?

In the United States, just three pharmaceutical giants hold patents that allow them to manufacture insulin: Eli Lilly, Sanofi and Novo Nordisk. Put together, the “big three” made more than $12 billion in profits in 2014, with insulin accounting for a large portion.

What makes this so worrisome is that the big three have simultaneously hiked their prices. From 2010 to 2015, the price of Lantus (made by Sanofi) went up by 168 percent; the price of Levemir (made by Novo Nordisk) rose by 169 percent; and the price of Humulin R U-500 (made by Eli Lilly) soared by 325 percent.

To make insulin affordable, we need more competition. Nothing would do this faster than a “generic” form of insulin. (Technically, because insulin is made using bacteria, it should be referred to as a “biosimilar” instead of a “generic.”) Unfortunately, there isn’t one available in the United States.

This is true, in no small part, because the big three have cleverly extended the lives of their patents, making incremental “improvements” to their insulin. It’s not clear whether the newer insulin products are significantly safer or more effective than their predecessors, yet the strategy has been effective: There is no generic insulin, and over 90 percent of privately insured patients with Type 2 diabetes who are prescribed insulin get the newer and more expensive products.
 




So true! While sending thousands of scientists to the unemployment line...to achieve "cost savings"...passed on to layers of useless management...who plan more mass layoffs of scientists. What a cycle!


The scientists have been pushed out (with the exception of the very well networked, you know, the ones who spend more time on the spiderweb of internal connections by email, phone, lunches, etc) over the past 10 years or so. Replaced by rent-a-scientists who are often subcontractors of our contractors, just hanging around week by week doing their check-box things

It's just so blindly futile and idiotic, in a word FUBAR, and also SNAFU. And all of these billions of dollars for non-productive drones get passed along to our healthcare system. Bravo!
 




The scientists have been pushed out (with the exception of the very well networked, you know, the ones who spend more time on the spiderweb of internal connections by email, phone, lunches, etc) over the past 10 years or so. Replaced by rent-a-scientists who are often subcontractors of our contractors, just hanging around week by week doing their check-box things

It's just so blindly futile and idiotic, in a word FUBAR, and also SNAFU. And all of these billions of dollars for non-productive drones get passed along to our healthcare system. Bravo!

how many billions did we borrow to buy back stock, to prop up the stock price, and when there is no cash flow left for a dividend, then what?
 




Good gosh, who forgot to close the door?

The Mannkind troll keep sneaking in here, replying to his own posts.

I get that seeing your "one-trick pony" company's share price plummet from $11 to $1 is disconcerting, but please, get a clue, nobody wants your lame technology (too variable on actual dose delivered); now leave us and every other insulin company alone. Go away.