Linagliptin launch

[Anonymous]

Will it basically be OUR salesforce that launches this drug? BI too involved in their drugs. Ventiv/CSO teams, well, they're contract people for a reason. I don't see them doing a whole helluva lot. Any thoughts?

 

[Anonymous]

When is the launch date?

 

[Appalachian Celebration]

Appalachian Celebration

jcl and the new team celebrate in his appalachian fortress of slothitude.
http://www.youtube.com/watch?v=MmZexg8sxyk

 

[Anonymous]

Linagliptin is GONE, Kaput..........

Check the Januvia capability in reducing A1C levels below Vs Linagliptin's 0.7%

A1C (%)
Change from baseline (adjusted mean‡)

Sitagliptin 50 mg bid + Metformin 500 mg bid

-1.4%

Sitagliptin 50 mg bid + Metformin 1000 mg bid

-1.9%

 

[Anonymous]

Will it basically be OUR salesforce that launches this drug? BI too involved in their drugs. Ventiv/CSO teams, well, they're contract people for a reason. I don't see them doing a whole helluva lot. Any thoughts?

Hopefully you will have no involvement in the launch. If you dont have a clue as to what is going on the product will fair better without you. Lilly is lucky to have a chance to launch a product as our portfolio is declining and headcount reductions not too far away. BI has multiple dedicated sales forces just us we do for the launch.

 

[Anonymous]

Will it basically be OUR salesforce that launches this drug? BI too involved in their drugs. Ventiv/CSO teams, well, they're contract people for a reason. I don't see them doing a whole helluva lot. Any thoughts?

I don't see either company doing much. BI know's nothing about diabetes, and will beat up the docs inappropriately, and turn them off. Lilly reps will show their baby pictures and try to make the doc feel good with their usual..."you're a thought leader doctor...what do you think? If you have to use a DPP4...please use mine...hee hee hee" Of the two team, I would bet on BI making it happen. However, in the end the drug will be a bust.

 

[Anonymous]

Re: Appalachian Celebration

jcl and the new team celebrate in his appalachian fortress of slothitude.
http://www.youtube.com/watch?v=MmZexg8sxyk

JCL's extended family of sister/wife/cousin-mother/brothers/uncles looks quite fetching...

 

[Anonymous]

Linagliptin is GONE, Kaput..........

Check the Januvia capability in reducing A1C levels below Vs Linagliptin's 0.7%

A1C (%)
Change from baseline (adjusted mean‡)

Sitagliptin 50 mg bid + Metformin 500 mg bid

-1.4%

Sitagliptin 50 mg bid + Metformin 1000 mg bid

-1.9%

Dumbass--those were patients who were previously treatment naive. You're taking credit for the work of metformin as well. Your shitty product only lowers A1c 0.5-0.7% as well.

With that said, this product is dead before it launches. It's #3 in a class of medications that has proven to be the least efficacious of all diabetes medications.

 

[Anonymous]

Linagliptin=no chance me too drug

Lilly=Montgomery Ward

Lechleiter=Taurel=Disaster

 

[Anonymous]

Linagliptin is GONE, Kaput..........

Check the Januvia capability in reducing A1C levels below Vs Linagliptin's 0.7%

A1C (%)
Change from baseline (adjusted mean‡)

Sitagliptin 50 mg bid + Metformin 500 mg bid

-1.4%

Sitagliptin 50 mg bid + Metformin 1000 mg bid

-1.9%

You're citing data involving use of metformin, idiot. Sitagliptin alone is the same as
Linagliptin w/ regard to A1C lowering. Metformin is cheap, too. Linagliptin will get it's share of the market, don't worry. Over time - probably sooner than you would imagine - BI will combine Lina with metformin and achieve the same, if not better, results. Calm down and enjoy watching Sita's market share eventually go Kaput. What'd you expect, NO competition in this class of drug? And there'll be others, too.

 

[Anonymous]

You are joking right? Onglyza has been on the market two years plus and they never hit their goal and are laying parts of the salesforce off. Linagliptin will be lucky if it does peak 150mm. These drugs just do not work...face it.

 

[Anonymous]

You're citing data involving use of metformin, idiot. Sitagliptin alone is the same as
Linagliptin w/ regard to A1C lowering. Metformin is cheap, too. Linagliptin will get it's share of the market, don't worry. Over time - probably sooner than you would imagine - BI will combine Lina with metformin and achieve the same, if not better, results. Calm down and enjoy watching Sita's market share eventually go Kaput. What'd you expect, NO competition in this class of drug? And there'll be others, too.

You moron!! BI did combine Lina w/metformin and the results are no higher than 0.7%!!!!

"Glycemic Parameters in Placebo-Controlled Study for TRADJENTA in Combination with Metformin*

A1C (%)
TRADJENTA 5 mg + Metformin Placebo + Metformin
Number of patients n = 513 n = 175
Baseline (mean) 8.1 8.0
Change from baseline (adjusted mean) -0.5 0.15

 

[Anonymous]

You're citing data involving use of metformin, idiot. Sitagliptin alone is the same as
Linagliptin w/ regard to A1C lowering. Metformin is cheap, too. Linagliptin will get it's share of the market, don't worry. Over time - probably sooner than you would imagine - BI will combine Lina with metformin and achieve the same, if not better, results. Calm down and enjoy watching Sita's market share eventually go Kaput. What'd you expect, NO competition in this class of drug? And there'll be others, too.

Linagliptin's maximum A1C reduction capability either as mono or combo is 0.7%!!!!!!!
Check the label....
tell me, how many of type II diabetics take mono nowadays? almost none!!!

 

[Anonymous]

You're citing data involving use of metformin, idiot. Sitagliptin alone is the same as
Linagliptin w/ regard to A1C lowering. Metformin is cheap, too. Linagliptin will get it's share of the market, don't worry. Over time - probably sooner than you would imagine - BI will combine Lina with metformin and achieve the same, if not better, results. Calm down and enjoy watching Sita's market share eventually go Kaput. What'd you expect, NO competition in this class of drug? And there'll be others, too.

You are dreaming brother..the next drug due to come out SGL2 will be third or fourth to market at well.. it is an absolute joke

 

[Anonymous]

Linagliptin's maximum A1C reduction capability either as mono or combo is 0.7%!!!!!!!
Check the label....
tell me, how many of type II diabetics take mono nowadays? almost none!!!

For that matter any drug, not just for diabetes II.

Cancer - 3-6
Diabetes - 2-3
blood pressure -2-4
anti-chol: 1-2
anticlot:2

See, the trend is to become Pablo Escrobaire! Push more drug in the mouth of illiterate people...say we make them live longer or longer with quality life. Population stats show quite opposite. Placebo effect alone is as effective as drugs. All drugs do is to remove unobservable effects...by "guiding" doctors (or your fucking use of "health care provider") to "see" what pharmaceuticals tell them to "see." More than 45% adverse side effects remain unreported due to too busy health care provider, or FDA cannot act because they have no way to act.

By 2100, this numbers could be in excess of 50 drugs combo (in ultra sweetened condensed milk, icecream or whey slurry) - ed, blood pressure, headache, antichol, anticlot, vomiting, sleeplessness, premature ejct, syphilis, aids, hpv, hsvI&II, hemorrhoids, yeast infection, anti-fart...

OR, eat well, sleep well and walk 3 miles per day. Don't work at drug pushers.

 

[Anonymous]

I don't see either company doing much. BI know's nothing about diabetes, and will beat up the docs inappropriately, and turn them off. Lilly reps will show their baby pictures and try to make the doc feel good with their usual..."you're a thought leader doctor...what do you think? If you have to use a DPP4...please use mine...hee hee hee" Of the two team, I would bet on BI making it happen. However, in the end the drug will be a bust.

Love it. It's going to be fun watching these teams sell this product.

 

[Anonymous]

For that matter any drug, not just for diabetes II.

Cancer - 3-6
Diabetes - 2-3
blood pressure -2-4
anti-chol: 1-2
anticlot:2

See, the trend is to become Pablo Escrobaire! Push more drug in the mouth of illiterate people...say we make them live longer or longer with quality life. Population stats show quite opposite. Placebo effect alone is as effective as drugs. All drugs do is to remove unobservable effects...by "guiding" doctors (or your fucking use of "health care provider") to "see" what pharmaceuticals tell them to "see." More than 45% adverse side effects remain unreported due to too busy health care provider, or FDA cannot act because they have no way to act.

By 2100, this numbers could be in excess of 50 drugs combo (in ultra sweetened condensed milk, icecream or whey slurry) - ed, blood pressure, headache, antichol, anticlot, vomiting, sleeplessness, premature ejct, syphilis, aids, hpv, hsvI&II, hemorrhoids, yeast infection, anti-fart...

OR, eat well, sleep well and walk 3 miles per day. Don't work at drug pushers.

Yes. Glutamine between meals during the day, and tryptophan before bed, plus good diet and exercise. Put these peddlers of dangerous drugs where they belong.

 

[Anonymous]

Yes. Glutamine between meals during the day, and tryptophan before bed, plus good diet and exercise. Put these peddlers of dangerous drugs where they belong.

Careful of tryptophan. Better would be 5HTP (10g/$20) as TRP can go oxidation...smelling fishy is good...no fishy..no good. Just drink milk whey 4-5 hours before usual sleep time..once the body acclimatizes [ac·cli·ma·tiz·es], you would be wondering why in hell I did not do during divorce. John, it can also do good to your body weight...you will shed btwn 50-80pounds in a year...and no need to eat $5 footlong...and then you can be less mean! Then you can rescue Lilly from dumpster that it is now in.

 

[Anonymous]

You moron!! BI did combine Lina w/metformin and the results are no higher than 0.7%!!!!

"Glycemic Parameters in Placebo-Controlled Study for TRADJENTA in Combination with Metformin*

A1C (%)
TRADJENTA 5 mg + Metformin Placebo + Metformin
Number of patients n = 513 n = 175
Baseline (mean) 8.1 8.0
Change from baseline (adjusted mean) -0.5 0.15

What's the difference? The A1Cs are the same....Sita+met has a 0.6 to 0.8 A1C advantage (at a higher baseline) over metformin monotherapy. Lina+met has 0.7 advantage (at a lower baseline) over met monotherapy. That's what the study says, Merck just got crafty in their analysis (sound familiar). The efficacy data between these drugs are all the same.

 

[Anonymous]

What's the difference? The A1Cs are the same....Sita+met has a 0.6 to 0.8 A1C advantage (at a higher baseline) over metformin monotherapy. Lina+met has 0.7 advantage (at a lower baseline) over met monotherapy. That's what the study says, Merck just got crafty in their analysis (sound familiar). The efficacy data between these drugs are all the same.

You mean the below data Sita plus MetF is same as Lina plus MetF AIC reduction data of 0.7%??? Please explain.....1.4% or 1.9% for Sita reduction Vs 0.7% for Lina??

A1C (%)
Change from baseline (adjusted mean‡)

Sitagliptin 50 mg bid + Metformin 500 mg bid

-1.4%

Sitagliptin 50 mg bid + Metformin 1000 mg bid

-1.9%