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I don't think it is the end because even though our meds are not selling as projected they are selling.  Ista is making money just not near the rate projected.  I would worry about a year or two from now when Bromday goes generic.  There is really nothing short of a major buyout to change the future.  Remura looks dead and it was the last ophthalmic med we had in pipeline.  There might be a downsize in the next several months.  Things are going to get tighter here and it will become even more unpleasant.