Illusion of job security in Oncology

anonymous

Guest
Been working in oncology for over three decades. For any potential MSL out there who thinks that oncology means job security, let me burst your bubble. And I mean BOOM!

Oncology is the most cut-throat pharma sector in the business. You might have the latest, greatest molecule and data on the planet, but someone is ALWAYS biting right on your heels. There is NO exclusivity in this business, as those of us who were in other therapeutic (e.g. cardiovascular, infectious diseases, etc.) can attest before we entered oncology/malignant hematology. This is NOT an area for the faint-hearted. You live and die by the latest PFS, OS, and AE data available. And it can turn on a femtometer. Look that up.

I do not mean to discourage anyone from entering into the oncology therapeutic area, but PLEASE…be aware: It does NOT offer the job security that you think it means. For BCOPs, you are as disposable as the molecule that just flunked its latest Phase whatever trial. For PhDs, you’re a dime a dozen. And I mean that literally having been a VP, Director, down the chain to MSL. For MDs/DOs who are not oncologists—well, let’s just say you better have another credential or you are no better off than your PharmD or PhD competitors.

Truth hurts, and well, so be it. Understand that today’s hot molecule is tomorrow’s scourge. You are an idiot if you think that Oncology/Hematology will guarantee you job security. As a matter of fact, quite the opposite.
 






Agree. Most newbies think that heme/onc will mean they always have a job. I feel sorry for them, in a way. It will take them their first unannounced firing, layoff or being frozen out of their email accounts and ordered onto a mass Teams or Zoom meeting telling them they are done to let them know there is no job security in this business. Biotech/pharma isn’t for wimps, and if you come into it without a spine then you learn a hard lesson early. And you never forget it.
 






Been working in oncology for over three decades. For any potential MSL out there who thinks that oncology means job security, let me burst your bubble. And I mean BOOM!

Oncology is the most cut-throat pharma sector in the business. You might have the latest, greatest molecule and data on the planet, but someone is ALWAYS biting right on your heels. There is NO exclusivity in this business, as those of us who were in other therapeutic (e.g. cardiovascular, infectious diseases, etc.) can attest before we entered oncology/malignant hematology. This is NOT an area for the faint-hearted. You live and die by the latest PFS, OS, and AE data available. And it can turn on a femtometer. Look that up.

I do not mean to discourage anyone from entering into the oncology therapeutic area, but PLEASE…be aware: It does NOT offer the job security that you think it means. For BCOPs, you are as disposable as the molecule that just flunked its latest Phase whatever trial. For PhDs, you’re a dime a dozen. And I mean that literally having been a VP, Director, down the chain to MSL. For MDs/DOs who are not oncologists—well, let’s just say you better have another credential or you are no better off than your PharmD or PhD competitors.

Truth hurts, and well, so be it. Understand that today’s hot molecule is tomorrow’s scourge. You are an idiot if you think that Oncology/Hematology will guarantee you job security. As a matter of fact, quite the opposite.


Sorry you feel that way about the MSL role, however your experience is not all that indicative of the Hem/Onc MSL role from my POV., which is OK and understandable.

I've worked mainly for Bay Area oncology startup biotechs over the last 27 years and have never been laid off, and fortunately I have been the beneficiary of some lucrative buyouts, where not only did we keep our jobs, we got retention bonuses to stay on for a year.

Additionally, it is a rare week where I do not get a call from a headhunter or a former colleague recruiting me to a new company. There are plenty of jobs out there.

I am truly sorry if you have not had a great experience in oncology, but to broad brush the role like the way you did isn't overly helpful. It sounds like you were venting, which CP is a great place for, but even your take on who is a 'dime a dozen' and to say molecules get replaced that quickly is also patently false.

I worked on several 'well known' oncolytics for the better part of their patent life and even in the small molecule era where there is a lot of 'me too' going on the indictions tend to be different or in different lines of therapies, et cetera. There doesn't seem to be a massive clinical differentiation these days, creating a zero sum game. Look at PD1 for instance. While Merck is ahead of the game BMS is still doing quite well. Two very similar MOA's, very little clinical differentiation at the molecular level and both still have a place.

I have led teams in a few different roles over the years - MSL's, Med Affairs, Med Com/Pub, and each credentialed partner brought something to the table. Perhaps you worked on some not so grea' drugs with some not so great people at some not so great companies during your 30 years?

I am curious have you been with mainly 'big pharma/bio bio's"? If so that would explain a lot about your perspective as mine is quite the opposite.

Good luck!
 






Sorry you feel that way about the MSL role, however your experience is not all that indicative of the Hem/Onc MSL role from my POV., which is OK and understandable.

I've worked mainly for Bay Area oncology startup biotechs over the last 27 years and have never been laid off, and fortunately I have been the beneficiary of some lucrative buyouts, where not only did we keep our jobs, we got retention bonuses to stay on for a year.

Additionally, it is a rare week where I do not get a call from a headhunter or a former colleague recruiting me to a new company. There are plenty of jobs out there.

I am truly sorry if you have not had a great experience in oncology, but to broad brush the role like the way you did isn't overly helpful. It sounds like you were venting, which CP is a great place for, but even your take on who is a 'dime a dozen' and to say molecules get replaced that quickly is also patently false.

I worked on several 'well known' oncolytics for the better part of their patent life and even in the small molecule era where there is a lot of 'me too' going on the indictions tend to be different or in different lines of therapies, et cetera. There doesn't seem to be a massive clinical differentiation these days, creating a zero sum game. Look at PD1 for instance. While Merck is ahead of the game BMS is still doing quite well. Two very similar MOA's, very little clinical differentiation at the molecular level and both still have a place.

I have led teams in a few different roles over the years - MSL's, Med Affairs, Med Com/Pub, and each credentialed partner brought something to the table. Perhaps you worked on some not so grea' drugs with some not so great people at some not so great companies during your 30 years?

I am curious have you been with mainly 'big pharma/bio bio's"? If so that would explain a lot about your perspective as mine is quite the opposite.

Good luck!

Original poster here. Wow! The Lithium really worked on you, sweetums. Been at this far longer than you. Like ten years longer in total. You are naive if you think Oncology THIS DECADE offers any stability at all. Either that, or you were under your boss’ desk, that I can’t speak to.

PD1/PD-1? ‘Scuse me, but fought that war. Same with CTL4As. Name-your-route TKIs, same. Sure we have met and probably I’ve smacked you down with facts over the years. Your naïveté, vis-a-vis, that PhDs ARE a dime-a-dozen, is patently incorrect. Or HOW ELSE can you explain the almost malignant proliferation of “How to Become a MSL” programs on LinkedIn, etc.,, in the past few years.

You’re a victim of your own fond n=1 recognizances; and you need to live with the fact that you are now obsolete. Deal with it.
 






Sorry you feel that way about the MSL role, however your experience is not all that indicative of the Hem/Onc MSL role from my POV., which is OK and understandable.

I've worked mainly for Bay Area oncology startup biotechs over the last 27 years and have never been laid off, and fortunately I have been the beneficiary of some lucrative buyouts, where not only did we keep our jobs, we got retention bonuses to stay on for a year.

Additionally, it is a rare week where I do not get a call from a headhunter or a former colleague recruiting me to a new company. There are plenty of jobs out there.

I am truly sorry if you have not had a great experience in oncology, but to broad brush the role like the way you did isn't overly helpful. It sounds like you were venting, which CP is a great place for, but even your take on who is a 'dime a dozen' and to say molecules get replaced that quickly is also patently false.

I worked on several 'well known' oncolytics for the better part of their patent life and even in the small molecule era where there is a lot of 'me too' going on the indictions tend to be different or in different lines of therapies, et cetera. There doesn't seem to be a massive clinical differentiation these days, creating a zero sum game. Look at PD1 for instance. While Merck is ahead of the game BMS is still doing quite well. Two very similar MOA's, very little clinical differentiation at the molecular level and both still have a place.

I have led teams in a few different roles over the years - MSL's, Med Affairs, Med Com/Pub, and each credentialed partner brought something to the table. Perhaps you worked on some not so grea' drugs with some not so great people at some not so great companies during your 30 years?

I am curious have you been with mainly 'big pharma/bio bio's"? If so that would explain a lot about your perspective as mine is quite the opposite.

Good luck!
 






Sorry you feel that way about the MSL role, however your experience is not all that indicative of the Hem/Onc MSL role from my POV., which is OK and understandable.

I've worked mainly for Bay Area oncology startup biotechs over the last 27 years and have never been laid off, and fortunately I have been the beneficiary of some lucrative buyouts, where not only did we keep our jobs, we got retention bonuses to stay on for a year.

Additionally, it is a rare week where I do not get a call from a headhunter or a former colleague recruiting me to a new company. There are plenty of jobs out there.

I am truly sorry if you have not had a great experience in oncology, but to broad brush the role like the way you did isn't overly helpful. It sounds like you were venting, which CP is a great place for, but even your take on who is a 'dime a dozen' and to say molecules get replaced that quickly is also patently false.

I worked on several 'well known' oncolytics for the better part of their patent life and even in the small molecule era where there is a lot of 'me too' going on the indictions tend to be different or in different lines of therapies, et cetera. There doesn't seem to be a massive clinical differentiation these days, creating a zero sum game. Look at PD1 for instance. While Merck is ahead of the game BMS is still doing quite well. Two very similar MOA's, very little clinical differentiation at the molecular level and both still have a place.

I have led teams in a few different roles over the years - MSL's, Med Affairs, Med Com/Pub, and each credentialed partner brought something to the table. Perhaps you worked on some not so grea' drugs with some not so great people at some not so great companies during your 30 years?

I am curious have you been with mainly 'big pharma/bio bio's"? If so that would explain a lot about your perspective as mine is quite the opposite.



Good luck!

Honeybunch, are you serious? Been at this business longer than you have, based on what history you supplied. PhD’s ARE a dime a dozen, in case you haven’t noticed them. I hire one or two of them every month for my team. I get at least 60 qualified CVs for my team every week. How many have you checked in the past few years…any? Do you have any bench experience whatsoever? Most of mine want to go out to Field Medical because it pays much more. Do any of yours want to come back INTO bench science? I’ll know you are lying if you say anything but “no”.

Another point, any MOA is already known to competitors. It’s already flashed around the scientific world by SciPubs for Investor Relations, published in an IB or presented so heavily that the investor community knows more about than the scientific community. If you don’t know that, you are naive beyond belief.

Finally, name one major NME that doesn’t have at least two or more major competitors already chasing it. Name them. From Isocitrate dehydrogenase inhibitors (bunch of them) to more highly targeted PARP inhibitors, please name at least one? You can’t. Clinicaltrials.gov or any pharma discovery database will prove you wrong.

So much for your blabbering.
 






Got is so you are/were a BIG PHARMA MSL"leader" at BMS...Arguably the least clinical and least respected group in oncology, so your rants now make so much more sense. The Eisai MSL's look like Nobel winners when compared to BMS MSL's. Bottom line, no one respects BMS from a clinical perspective. That should make you angry and perhaps why you feel a lack of job security. If I worked at BMS I would too.

Here is a news flash for you...big pharma sucks, it has always sucked, it has always paid a lot less, and always had a lot of volatility in terms of layoffs. It has become a metric driven culture that has turned MSL's into a de facto sales reps. Also the biggest myth out there is that "big is safe". It is quite the opposite.

You hire two MSL positions every month or so? You must be a terrible leader and person to work for with turnover that high. Based on your bitter, holier than thou posts, it makes sense that you have high turnover as the equation is pretty simple:

Bad company + bad boss = high turnover.

I would have to really reach back to see when we last had an MSL opening at my current company...I know this, it has been years.

Oh so my 27 years in the industry are meaningless? Arrogant much? Prior to joining industry I worked on the bench with IL-2, so think what you will, however it's really sad that you are so insecure that you believe 10 years more of "industry experience" at this point is meaningfully different and makes you 'the authority' on anything. So you joined in the mid 80's and I joined in the mid 90's. I can tell you this, those two eras are far more alike versus what the industry is like today.

You sound very insecure, but I'll play along...after Chiron/Cetus (worked closely with T. Ribas and S O'Day...you may have heard of them from your Melanoma experience) I joined the medical team for the clinical trial phase and launch of four of the biggest breakthroughs in oncology with Tarceva, Avastin, Rituxan, and Herceptin. I worked directly with the both D. Slamon and F. Kabbinavar while at DNA and am still friends with them both to this day, so I am very confident in my experience, not arrogant like you, but confident, since I have earned their respect and have scientific conversations with folks of that caliber. I thought we could have an intellectual conversation, well that was until you said, "you probably smacked someone down" which is idiotic and doesn't sound like you have the emotional intelligence of a clinician. Maybe you are a sales rep in disguise?

I am sorry if your experience in oncology has been less than you were hoping, at least lately, unfortunately you sound angry, so I am guessing you are have been laid off recently(why else title the original post as you did)and that sucks for sure, but your experience is yours alone, as my expense is mine alone.

Clearly we have had very different experiences past and present, which is OK. If you have not been laid off what was the purpose of your post? Just to complain to scare younger MSL's away form oncology? Why?

You gave your insights, I gave my insights that differed from yours, which clearly struck a nerve...guessing your opinion is the only one that is ever right and everyone else is wrong? Gee no wonder you have so much turnover.

Here is a tip for you...don't work for big oncology companies based in NJ/NY. There is a reason why the good oncology biotechs, based mainly in the Bay Area and Boston, rarely slum it and hire MSL's out of big pharma...specifically BMS.
 






Not the poster you are replying to, but why all the name calling and hostility toward them? YMMV, but no job is perfect, and considering how many Onc teams have been restructured in the past year—it’s understandable that people are nervous about the future. I’m just a lowly MSL in CAR-T cell therapy, and our OS/PFS data isn’t that well established yet. We’re getting there, but until it does, of course I am always anxious that FDA’s whims or a management shakeup might see us all out the door tomorrow. Fact of life in corporate America.
 






Got is so you are/were a BIG PHARMA MSL"leader" at BMS...Arguably the least clinical and least respected group in oncology, so your rants now make so much more sense. The Eisai MSL's look like Nobel winners when compared to BMS MSL's. Bottom line, no one respects BMS from a clinical perspective. That should make you angry and perhaps why you feel a lack of job security. If I worked at BMS I would too.

Here is a news flash for you...big pharma sucks, it has always sucked, it has always paid a lot less, and always had a lot of volatility in terms of layoffs. It has become a metric driven culture that has turned MSL's into a de facto sales reps. Also the biggest myth out there is that "big is safe". It is quite the opposite.

You hire two MSL positions every month or so? You must be a terrible leader and person to work for with turnover that high. Based on your bitter, holier than thou posts, it makes sense that you have high turnover as the equation is pretty simple:

Bad company + bad boss = high turnover.

I would have to really reach back to see when we last had an MSL opening at my current company...I know this, it has been years.

Oh so my 27 years in the industry are meaningless? Arrogant much? Prior to joining industry I worked on the bench with IL-2, so think what you will, however it's really sad that you are so insecure that you believe 10 years more of "industry experience" at this point is meaningfully different and makes you 'the authority' on anything. So you joined in the mid 80's and I joined in the mid 90's. I can tell you this, those two eras are far more alike versus what the industry is like today.

You sound very insecure, but I'll play along...after Chiron/Cetus (worked closely with T. Ribas and S O'Day...you may have heard of them from your Melanoma experience) I joined the medical team for the clinical trial phase and launch of four of the biggest breakthroughs in oncology with Tarceva, Avastin, Rituxan, and Herceptin. I worked directly with the both D. Slamon and F. Kabbinavar while at DNA and am still friends with them both to this day, so I am very confident in my experience, not arrogant like you, but confident, since I have earned their respect and have scientific conversations with folks of that caliber. I thought we could have an intellectual conversation, well that was until you said, "you probably smacked someone down" which is idiotic and doesn't sound like you have the emotional intelligence of a clinician. Maybe you are a sales rep in disguise?

I am sorry if your experience in oncology has been less than you were hoping, at least lately, unfortunately you sound angry, so I am guessing you are have been laid off recently(why else title the original post as you did)and that sucks for sure, but your experience is yours alone, as my expense is mine alone.

Clearly we have had very different experiences past and present, which is OK. If you have not been laid off what was the purpose of your post? Just to complain to scare younger MSL's away form oncology? Why?

You gave your insights, I gave my insights that differed from yours, which clearly struck a nerve...guessing your opinion is the only one that is ever right and everyone else is wrong? Gee no wonder you have so much turnover.

Here is a tip for you...don't work for big oncology companies based in NJ/NY. There is a reason why the good oncology biotechs, based mainly in the Bay Area and Boston, rarely slum it and hire MSL's out of big pharma...specifically BMS.

When was the last time you had your Lithium level checked?
 






Got is so you are/were a BIG PHARMA MSL"leader" at BMS...Arguably the least clinical and least respected group in oncology, so your rants now make so much more sense. The Eisai MSL's look like Nobel winners when compared to BMS MSL's. Bottom line, no one respects BMS from a clinical perspective. That should make you angry and perhaps why you feel a lack of job security. If I worked at BMS I would too.

Here is a news flash for you...big pharma sucks, it has always sucked, it has always paid a lot less, and always had a lot of volatility in terms of layoffs. It has become a metric driven culture that has turned MSL's into a de facto sales reps. Also the biggest myth out there is that "big is safe". It is quite the opposite.

You hire two MSL positions every month or so? You must be a terrible leader and person to work for with turnover that high. Based on your bitter, holier than thou posts, it makes sense that you have high turnover as the equation is pretty simple:

Bad company + bad boss = high turnover.

I would have to really reach back to see when we last had an MSL opening at my current company...I know this, it has been years.

Oh so my 27 years in the industry are meaningless? Arrogant much? Prior to joining industry I worked on the bench with IL-2, so think what you will, however it's really sad that you are so insecure that you believe 10 years more of "industry experience" at this point is meaningfully different and makes you 'the authority' on anything. So you joined in the mid 80's and I joined in the mid 90's. I can tell you this, those two eras are far more alike versus what the industry is like today.

You sound very insecure, but I'll play along...after Chiron/Cetus (worked closely with T. Ribas and S O'Day...you may have heard of them from your Melanoma experience) I joined the medical team for the clinical trial phase and launch of four of the biggest breakthroughs in oncology with Tarceva, Avastin, Rituxan, and Herceptin. I worked directly with the both D. Slamon and F. Kabbinavar while at DNA and am still friends with them both to this day, so I am very confident in my experience, not arrogant like you, but confident, since I have earned their respect and have scientific conversations with folks of that caliber. I thought we could have an intellectual conversation, well that was until you said, "you probably smacked someone down" which is idiotic and doesn't sound like you have the emotional intelligence of a clinician. Maybe you are a sales rep in disguise?

I am sorry if your experience in oncology has been less than you were hoping, at least lately, unfortunately you sound angry, so I am guessing you are have been laid off recently(why else title the original post as you did)and that sucks for sure, but your experience is yours alone, as my expense is mine alone.

Clearly we have had very different experiences past and present, which is OK. If you have not been laid off what was the purpose of your post? Just to complain to scare younger MSL's away form oncology? Why?

You gave your insights, I gave my insights that differed from yours, which clearly struck a nerve...guessing your opinion is the only one that is ever right and everyone else is wrong? Gee no wonder you have so much turnover.

Here is a tip for you...don't work for big oncology companies based in NJ/NY. There is a reason why the good oncology biotechs, based mainly in the Bay Area and Boston, rarely slum it and hire MSL's out of big pharma...specifically BMS.

Never worked for BMS. That’s a figment of your diseased mind. Work for current Boston biotech, and I know we’ve crossed paths, because I know from your writing and speech style who you are. And you have lost debates to me, multiple times—not only on scientific but on managerial matters. The fact that you resort to name-dropping tells everyone else all they need to know—you want to be associated with people, but without your own accomplishments. Dismisses your entire credibility. Have a miserable obscurity!
 






Never worked for BMS. That’s a figment of your diseased mind. Work for current Boston biotech, and I know we’ve crossed paths, because I know from your writing and speech style who you are. And you have lost debates to me, multiple times—not only on scientific but on managerial matters. The fact that you resort to name-dropping tells everyone else all they need to know—you want to be associated with people, but without your own accomplishments. Dismisses your entire credibility. Have a miserable obscurity!


So you were in the PD1 battles and worked on CTLA-4 and did not work at BMS?

Perhaps you over did it on the fentanyl…
 






So you were in the PD1 battles and worked on CTLA-4 and did not work at BMS?

Perhaps you over did it on the fentanyl…


Me thinks you caught her in a lie!

I was thinking the same thing...only company with CTLA-4 and PD1 is BMS. This lady is delusional.

Not only is she a world renowned MSL who "smacks down" everyone and anyone she comes in contact with she is also a forensic criminologists who can identify writing styles, and speech styles, even without hearing someone speak!!! Her talents are limitless!!!
 












Me thinks you caught her in a lie!

I was thinking the same thing...only company with CTLA-4 and PD1 is BMS. This lady is delusional.

Not only is she a world renowned MSL who "smacks down" everyone and anyone she comes in contact with she is also a forensic criminologists who can identify writing styles, and speech styles, even without hearing someone speak!!! Her talents are limitless!!!

You certainly make a lot of ASSumptions about who made that post. You realize multiple labs were making inquiries into those pathways? If not, you suffer from a serious radical craniorectal impaction—but then again-that’s already been proved by your post. I’m not the OP, nor the follow up poster, but man, are you dumb!!! I have worked at SIX labs that were working on PD1/PDL1 and CTL4A inhibitor pathway Phase I candidates before you were crapping in your diaper. None of these pathways are new discoveries. I worked at Jim Allison’s lab way back when. Can any of you say that? I did the plates that showed confirmed his hypotheses were correct, and I have drinks with him whenever I want. Screw you and your name-bombing. I was there in the lab. I *DID* the work. The rest of you are all just poseurs. Unless you actually were IN. THAT. LAB, you suck ass. And are liars.
 






You certainly make a lot of ASSumptions about who made that post. You realize multiple labs were making inquiries into those pathways? If not, you suffer from a serious radical craniorectal impaction—but then again-that’s already been proved by your post. I’m not the OP, nor the follow up poster, but man, are you dumb!!! I have worked at SIX labs that were working on PD1/PDL1 and CTL4A inhibitor pathway Phase I candidates before you were crapping in your diaper. None of these pathways are new discoveries. I worked at Jim Allison’s lab way back when. Can any of you say that? I did the plates that showed confirmed his hypotheses were correct, and I have drinks with him whenever I want. Screw you and your name-bombing. I was there in the lab. I *DID* the work. The rest of you are all just poseurs. Unless you actually were IN. THAT. LAB, you suck ass. And are liars.


Sure ya did…

This is what you wrote:

PD1/PD-1? ‘Scuse me, but fought that war. Same with CTL4As.

What war were you fighting in the lab as an MSL at a pharmaceutical company? If this was pre commercialization how would you be fighting with anyone? You are making yourself look more foolish than before. You were an MSL at BMS and got laid off.

We know who you are…and we are not surprised.
 






Sure ya did…

This is what you wrote:

PD1/PD-1? ‘Scuse me, but fought that war. Same with CTL4As.

What war were you fighting in the lab as an MSL at a pharmaceutical company? If this was pre commercialization how would you be fighting with anyone? You are making yourself look more foolish than before. You were an MSL at BMS and got laid off.

We know who you are…and we are not surprised.
Sorry to burst your hallucination, but never worked for BMS. Never. They bought both Nivo and Ipi. They didn’t develop those technologies themselves, bum ditch.
 












Sorry to burst your hallucination, but never worked for BMS. Never. They bought both Nivo and Ipi. They didn’t develop those technologies themselves, bum ditch.

You did not work at Medarex. No one from the bench went to an MSL role after their time there, also the work streams for CTLA-4 and PD1 were not the same so no way you worked on both...oh and then you jumped to an MSL role? Yeah right.

You were an MSL at BMS. Most of us know who you are. This is not your first bitter rant on CP or at meetings. Guess you were surprised you got let go...no one else is.

Keep lying...you are digging your hole deeper.
 






Not even fracking close. Not female, never worked for BMS. You do realize many companies worked on projects for PDL1/PD1, and CTL4A at same time, or you ARE that fracking stupid. Ever consider a Euro or Asian company that had research going at the same time? Of course you didn’t, bonehead! Now shovel the crap out of your head and THINK AGAIN. Who else had projects going OUTSIDE of the US? Hmmm……
 






Not even fracking close. Not female, never worked for BMS. You do realize many companies worked on projects for PDL1/PD1, and CTL4A at same time, or you ARE that fracking stupid. Ever consider a Euro or Asian company that had research going at the same time? Of course you didn’t, bonehead! Now shovel the crap out of your head and THINK AGAIN. Who else had projects going OUTSIDE of the US? Hmmm……
Fracking? stfu