How To Relaunch XXR

Anonymous

Guest
OK, I am an inVentiv Rep and will not be retained (but not for lack of effort).

I have some sweat equity invested in XXR and am sorry for everyone involved that it has not attained the rosy forecast projections.

I have been a part of numerous successful product launches for other organizations and this is my (or collective we) first failure.

Here is what could be done to market this drug successfully or be applied to MNK 155:

Invest in direct hire reps and train and compensate them properly. Legacy reps have a vested interest in the ongoing and long-term success of an organization. Career advancement opportunities motivate reps and the whole "contract" mindset undermines commitment to the organization and the reps alike.

Secure competitive formulary status on Medicare, Medicaid and Commercial plans. Obviously this means lowering your profit margins but you're competing in a heavily genericized, scrutinized and regulated therapeutic category. Every managed care plan will cover generic Percocet. HCPs don't even have to think about it. In my state, only 1 commercial plan covered XXR without a Prior Authorization. Emphasize coverage on regional and local health plans to gain traction.

Invest in some meaningful clinical studies that differentiate XXR or MNK 155 from generic options. The pharmacokinetic overlay graphic showing the roller-coaster serum levels of Percocet (dosed every 4-6 hours) vs XXR dosed BID that tells an impactful story. Take it a step further by doing a G.I. study showing the increased rates of nausea with Percocet spiking in the gut every 4-6 hours vs XXR dosed BID with a controlled steady release. The biggest patient complaint with Percocet and other pain meds is nausea and if XXR can demonstrate increased tolerability, with less discontinuation and call backs to the office, you have a differentiator that resonates with HCPs and their staff.

Dedicate a page in an all-inclusive sales aid that articulates the costs of slip and fall accidents associated with patients taking medications that negatively impact their equilibrium. XXR enables patients to sleep through the night and not have to get up to re-dose every 4-6 hours and throw more water on their bladder, which can trigger another reason to get up groggy and dizzy and at risk for a fall).

Establish a competitive pharmacy stocking program with MNK 155 up front with chain and independent pharmacies. Offer a buy 1 get 1 free stock bottle with the ability to exchange any unopened expired bottle for a new one if necessary down the road. For chain pharmacies, ship the free bottle to another high volume location not yet stocked to expand the reach and availability.

Hire some sales and marketing executive talent with extensive experience launching and promoting scheduled pain medications. Your existing executive team blew it for XXR before it was even launched. Time to clean house and poach some talent away from Purdue or wherever they have had documented success in the core MNK therapeutic categories.110% sales goals, new target lists every quarter (can ZS Associates), 4 sales aids to tell the story, no web on-demand sales/education site for the no-sees of the world, Regional Managers encouraging reps to stalk surgeons in parking lots at 5:30 a.m. and p.m. or to work on Saturdays...absolutely amazing direction coming from six-figure compensated executives.

These are but a few of the issues/challenges/opportunities. I am sure to be ridiculed and scorned and will enjoy viewing any other constructive criticism/suggestions. It's time to move on but I have genuine remorse for a drug and organization that I had high hopes for but collectively fell short. I was getting scripts until they were immediately bounced because of a lack of insurance coverage and patients found it too challenging to find a pharmacy stocking it. Docs and their staff found it too much of a hassle to continue to prescribe XXR and shut it down rapidly. MNK needs to have all the pieces of the puzzle in place to successfully compete in this hyper competitive pain category dominated by generics and cost concerns.

Let the arrows fly and dead wood comments begin...

P.S. Good luck and best wishes for continued success for those who found a way to attain their numbers! Your relationships, hard work and M/C coverage obviously made a difference.
 






Very well stated. You are obviously a very bright, professional articulate and well versed rep. XXR was doomed from those in their ivory tower who never carried a bag and do not understand reality in the field.
I wish you the best. May you go to a company where you can utilize your talents and be well recognized. God Speed.
 












OK, I am an inVentiv Rep and will not be retained (but not for lack of effort).

I have some sweat equity invested in XXR and am sorry for everyone involved that it has not attained the rosy forecast projections.

I have been a part of numerous successful product launches for other organizations and this is my (or collective we) first failure.

Here is what could be done to market this drug successfully or be applied to MNK 155:

Invest in direct hire reps and train and compensate them properly. Legacy reps have a vested interest in the ongoing and long-term success of an organization. Career advancement opportunities motivate reps and the whole "contract" mindset undermines commitment to the organization and the reps alike.

Secure competitive formulary status on Medicare, Medicaid and Commercial plans. Obviously this means lowering your profit margins but you're competing in a heavily genericized, scrutinized and regulated therapeutic category. Every managed care plan will cover generic Percocet. HCPs don't even have to think about it. In my state, only 1 commercial plan covered XXR without a Prior Authorization. Emphasize coverage on regional and local health plans to gain traction.

Invest in some meaningful clinical studies that differentiate XXR or MNK 155 from generic options. The pharmacokinetic overlay graphic showing the roller-coaster serum levels of Percocet (dosed every 4-6 hours) vs XXR dosed BID that tells an impactful story. Take it a step further by doing a G.I. study showing the increased rates of nausea with Percocet spiking in the gut every 4-6 hours vs XXR dosed BID with a controlled steady release. The biggest patient complaint with Percocet and other pain meds is nausea and if XXR can demonstrate increased tolerability, with less discontinuation and call backs to the office, you have a differentiator that resonates with HCPs and their staff.

Dedicate a page in an all-inclusive sales aid that articulates the costs of slip and fall accidents associated with patients taking medications that negatively impact their equilibrium. XXR enables patients to sleep through the night and not have to get up to re-dose every 4-6 hours and throw more water on their bladder, which can trigger another reason to get up groggy and dizzy and at risk for a fall).

Establish a competitive pharmacy stocking program with MNK 155 up front with chain and independent pharmacies. Offer a buy 1 get 1 free stock bottle with the ability to exchange any unopened expired bottle for a new one if necessary down the road. For chain pharmacies, ship the free bottle to another high volume location not yet stocked to expand the reach and availability.

Hire some sales and marketing executive talent with extensive experience launching and promoting scheduled pain medications. Your existing executive team blew it for XXR before it was even launched. Time to clean house and poach some talent away from Purdue or wherever they have had documented success in the core MNK therapeutic categories.110% sales goals, new target lists every quarter (can ZS Associates), 4 sales aids to tell the story, no web on-demand sales/education site for the no-sees of the world, Regional Managers encouraging reps to stalk surgeons in parking lots at 5:30 a.m. and p.m. or to work on Saturdays...absolutely amazing direction coming from six-figure compensated executives.

These are but a few of the issues/challenges/opportunities. I am sure to be ridiculed and scorned and will enjoy viewing any other constructive criticism/suggestions. It's time to move on but I have genuine remorse for a drug and organization that I had high hopes for but collectively fell short. I was getting scripts until they were immediately bounced because of a lack of insurance coverage and patients found it too challenging to find a pharmacy stocking it. Docs and their staff found it too much of a hassle to continue to prescribe XXR and shut it down rapidly. MNK needs to have all the pieces of the puzzle in place to successfully compete in this hyper competitive pain category dominated by generics and cost concerns.

Let the arrows fly and dead wood comments begin...

P.S. Good luck and best wishes for continued success for those who found a way to attain their numbers! Your relationships, hard work and M/C coverage obviously made a difference.

The rate of nausea from XXR is somewhat higher than for Percocet. That is exactly why a patient is better off with Percocet--because if they have nausea, they can space out their doses and take as little as possible. Also, a high percentage of patients are nauseous immediately after awaking from anesthesia--there is no way that this person should have to commit to a drug that can cause 12 hours of nausea.
 






OK, I am an inVentiv Rep and will not be retained (but not for lack of effort).

I have some sweat equity invested in XXR and am sorry for everyone involved that it has not attained the rosy forecast projections.

I have been a part of numerous successful product launches for other organizations and this is my (or collective we) first failure.

Here is what could be done to market this drug successfully or be applied to MNK 155:

Invest in direct hire reps and train and compensate them properly. Legacy reps have a vested interest in the ongoing and long-term success of an organization. Career advancement opportunities motivate reps and the whole "contract" mindset undermines commitment to the organization and the reps alike.

Secure competitive formulary status on Medicare, Medicaid and Commercial plans. Obviously this means lowering your profit margins but you're competing in a heavily genericized, scrutinized and regulated therapeutic category. Every managed care plan will cover generic Percocet. HCPs don't even have to think about it. In my state, only 1 commercial plan covered XXR without a Prior Authorization. Emphasize coverage on regional and local health plans to gain traction.

Invest in some meaningful clinical studies that differentiate XXR or MNK 155 from generic options. The pharmacokinetic overlay graphic showing the roller-coaster serum levels of Percocet (dosed every 4-6 hours) vs XXR dosed BID that tells an impactful story. Take it a step further by doing a G.I. study showing the increased rates of nausea with Percocet spiking in the gut every 4-6 hours vs XXR dosed BID with a controlled steady release. The biggest patient complaint with Percocet and other pain meds is nausea and if XXR can demonstrate increased tolerability, with less discontinuation and call backs to the office, you have a differentiator that resonates with HCPs and their staff.

Dedicate a page in an all-inclusive sales aid that articulates the costs of slip and fall accidents associated with patients taking medications that negatively impact their equilibrium. XXR enables patients to sleep through the night and not have to get up to re-dose every 4-6 hours and throw more water on their bladder, which can trigger another reason to get up groggy and dizzy and at risk for a fall).

Establish a competitive pharmacy stocking program with MNK 155 up front with chain and independent pharmacies. Offer a buy 1 get 1 free stock bottle with the ability to exchange any unopened expired bottle for a new one if necessary down the road. For chain pharmacies, ship the free bottle to another high volume location not yet stocked to expand the reach and availability.

Hire some sales and marketing executive talent with extensive experience launching and promoting scheduled pain medications. Your existing executive team blew it for XXR before it was even launched. Time to clean house and poach some talent away from Purdue or wherever they have had documented success in the core MNK therapeutic categories.110% sales goals, new target lists every quarter (can ZS Associates), 4 sales aids to tell the story, no web on-demand sales/education site for the no-sees of the world, Regional Managers encouraging reps to stalk surgeons in parking lots at 5:30 a.m. and p.m. or to work on Saturdays...absolutely amazing direction coming from six-figure compensated executives.

These are but a few of the issues/challenges/opportunities. I am sure to be ridiculed and scorned and will enjoy viewing any other constructive criticism/suggestions. It's time to move on but I have genuine remorse for a drug and organization that I had high hopes for but collectively fell short. I was getting scripts until they were immediately bounced because of a lack of insurance coverage and patients found it too challenging to find a pharmacy stocking it. Docs and their staff found it too much of a hassle to continue to prescribe XXR and shut it down rapidly. MNK needs to have all the pieces of the puzzle in place to successfully compete in this hyper competitive pain category dominated by generics and cost concerns.

Let the arrows fly and dead wood comments begin...

P.S. Good luck and best wishes for continued success for those who found a way to attain their numbers! Your relationships, hard work and M/C coverage obviously made a difference.

I completely agree with you about hiring a competitively paid permanent salesforce. A few years ago, Pfizer let go of 90% of their salesforce and went all contract. A few years later, they cancelled their contract and hired people directly again.

A contract salesforce can only be 100% dedicated when their job is secure. If they suspect that they will get laid off in the near future, they will spend most of their time trying to secure a permanent position.
 






Great ideas and post. These are the types of post that CafePharma was intended to be used for and not the moaners. What could we do better...

I'd add or underscore:
1. Medicare coverage
2. Updating the MI and data processes. The Reps need to decide who is in the iPad beyond a hard target list. We can make it easier to add and remove prescribers and document specialities. i.e. DDS or Oral surgeons?
3. Give the field some studies with more specialties. Oral Surgeons, ORS, ENT, OB/GYN
4. Unit dose and very aggressive hospital pricing like $0.25. Get the patients in the hospital and the retail prescriptions on discharge. It is an old drug that we manufacture. Outside of maybe some special costs for the delivery system, it cannot cost much to manufacture.
5. Keep the open targets arrangement. (Paying for dirt)
6. Kill the activity measurements, i.e. targets seen, pharmacies seen and open up the rep to run their franchise. it would free up the reps to go get the business.
7. Emphasize the sleep aspect of healing? REM sleep needs, (nice slip and fall in the dark angle above)
8. Love the bladder as another reason to have to get up at night...work this
9. Have some sort of video for the iPad about Polyox. It can state multiple times that we do not have the labeling, we have the ingredient and properties, but no labeling. IT IS in the ingredients listing. The reps are not allowed to discuss it. Only the video.
10. Not required but a cut away 3-D tablet would emphasize the different layers and technology behind the release. Almost more importantly, prescribers can hold it and take the cut-a-way part off. Anytime you stimulate another sense, like touch, you make it more memorable.
11. Put somewhere a chart of half-lives for the other acute pain meds. The 5.6 hour half life can help if we put it out there somewhere
12. Work the 'X' somehow. They cannot remember the name.
13. Be able to update the Pharmacy Lists somehow. I had many stocked stores that never showed up on the printable lists.
14. Find a way to give credit for PPI RX's that don't show up in IMS.
15. Find a VP who once was a rep, somewhere.

I left MNK sometime ago and found a great place. I still think about how it could have been better.

There are lessons to be learned for those who will examine the last year of poor decisions. The others are condemned to repeat the errors.
 






Actually you forgot the actual best advice - fire the executive clown patrol that doesnt live in St Louis but followed the short bus that MT got off of.... once they are all fired....wait 5 sec and hire the OP to lead the launch.

OP your thoughtful well reasoned approach is a clear example of exactly what is missing at MNK these days - executive talent. Your knowledge and experience are how this company originally succeeded - listening to the field, building relationships, trusting the team to execute. MT changed this to ignore the field, burn relationships and execute the team.
 






OK, I am an inVentiv Rep and will not be retained (but not for lack of effort).

I have some sweat equity invested in XXR and am sorry for everyone involved that it has not attained the rosy forecast projections.

I have been a part of numerous successful product launches for other organizations and this is my (or collective we) first failure.

Here is what could be done to market this drug successfully or be applied to MNK 155:

Invest in direct hire reps and train and compensate them properly. Legacy reps have a vested interest in the ongoing and long-term success of an organization. Career advancement opportunities motivate reps and the whole "contract" mindset undermines commitment to the organization and the reps alike.

Secure competitive formulary status on Medicare, Medicaid and Commercial plans. Obviously this means lowering your profit margins but you're competing in a heavily genericized, scrutinized and regulated therapeutic category. Every managed care plan will cover generic Percocet. HCPs don't even have to think about it. In my state, only 1 commercial plan covered XXR without a Prior Authorization. Emphasize coverage on regional and local health plans to gain traction.

Invest in some meaningful clinical studies that differentiate XXR or MNK 155 from generic options. The pharmacokinetic overlay graphic showing the roller-coaster serum levels of Percocet (dosed every 4-6 hours) vs XXR dosed BID that tells an impactful story. Take it a step further by doing a G.I. study showing the increased rates of nausea with Percocet spiking in the gut every 4-6 hours vs XXR dosed BID with a controlled steady release. The biggest patient complaint with Percocet and other pain meds is nausea and if XXR can demonstrate increased tolerability, with less discontinuation and call backs to the office, you have a differentiator that resonates with HCPs and their staff.

Dedicate a page in an all-inclusive sales aid that articulates the costs of slip and fall accidents associated with patients taking medications that negatively impact their equilibrium. XXR enables patients to sleep through the night and not have to get up to re-dose every 4-6 hours and throw more water on their bladder, which can trigger another reason to get up groggy and dizzy and at risk for a fall).

Establish a competitive pharmacy stocking program with MNK 155 up front with chain and independent pharmacies. Offer a buy 1 get 1 free stock bottle with the ability to exchange any unopened expired bottle for a new one if necessary down the road. For chain pharmacies, ship the free bottle to another high volume location not yet stocked to expand the reach and availability.

Hire some sales and marketing executive talent with extensive experience launching and promoting scheduled pain medications. Your existing executive team blew it for XXR before it was even launched. Time to clean house and poach some talent away from Purdue or wherever they have had documented success in the core MNK therapeutic categories.110% sales goals, new target lists every quarter (can ZS Associates), 4 sales aids to tell the story, no web on-demand sales/education site for the no-sees of the world, Regional Managers encouraging reps to stalk surgeons in parking lots at 5:30 a.m. and p.m. or to work on Saturdays...absolutely amazing direction coming from six-figure compensated executives.

These are but a few of the issues/challenges/opportunities. I am sure to be ridiculed and scorned and will enjoy viewing any other constructive criticism/suggestions. It's time to move on but I have genuine remorse for a drug and organization that I had high hopes for but collectively fell short. I was getting scripts until they were immediately bounced because of a lack of insurance coverage and patients found it too challenging to find a pharmacy stocking it. Docs and their staff found it too much of a hassle to continue to prescribe XXR and shut it down rapidly. MNK needs to have all the pieces of the puzzle in place to successfully compete in this hyper competitive pain category dominated by generics and cost concerns.

Let the arrows fly and dead wood comments begin...

P.S. Good luck and best wishes for continued success for those who found a way to attain their numbers! Your relationships, hard work and M/C coverage obviously made a difference.

Fantasy land and completely unreasonable.
Lets go down the line
Legacy reps?? Are you kidding? for this cheap outfit?

Medicaid status??what a joke. It takes months to get on medicaid and the product has to be given away, not likely with this greed bunch. You will never get medicaid status for a "me too" product in any state. Medicare, it wasw too late to apply , but why would you give a 68yr old oxycodone?? stupid.

Clinical studies, would take years for them to save any of our jobs. And they may turn out to be inconclusive or worse, show no difference. LOL

Competitive pharmacy stocking, good idea, but it would cost too much out of the bounus plans for our leaders

executive team, a complete joike, I think they should hire a branch manager from ATT or Enterprise rental cars, that would have been their idea of "executive talant"

Surgeons at 530AM ?? F*&k you
 






Regarding Medicare coverage, yes, we launched too late for 2014, but there was plenty of time to get Med D coverage for 2015, yet MNK is not pursuing it!!!!
And yes, 68, 78, and even 88 year olds need and do take Percocet!
 






A clinical study that measure gastric acid levels 30 minutes post dose, 1 hour post dose, 2 hours post dose, 4 hours post dose for both XXR and Percocet; then at 6, 8, 10 for XXR, is a study that can be rapidly executed, reviewed for significance and submitted to DDMAC/FDA for review if it pans out.

It's not as if you are doing an extended outcomes study that takes years to complete like seeking mortality data or cv event reductions.

Those spikes in acid levels in the gut dosing Percocet every 4-6 hours would suggest increased levels of nausea vs the slow, controlled release of XXR over 12 hours. The initial measures would likely be comparable between the two for the first 2-3 hours but it seems plausible that XXR would have lower overall gastric acid levels over time vs the short acting blast of Percocet every 4-6 hours. Would the gastric acid spikes of Percocet mirror the serum level spikes as depicted in our sales aids?

Not a costly study to conduct and in this uber competitive category, there has to be some clinical (efficacy, tolerabilty, safety) or cost benefits to justify mc plans to cover it and for hcps to prescribe it.
 






A clinical study that measure gastric acid levels 30 minutes post dose, 1 hour post dose, 2 hours post dose, 4 hours post dose for both XXR and Percocet; then at 6, 8, 10 for XXR, is a study that can be rapidly executed, reviewed for significance and submitted to DDMAC/FDA for review if it pans out.

It's not as if you are doing an extended outcomes study that takes years to complete like seeking mortality data or cv event reductions.

Those spikes in acid levels in the gut dosing Percocet every 4-6 hours would suggest increased levels of nausea vs the slow, controlled release of XXR over 12 hours. The initial measures would likely be comparable between the two for the first 2-3 hours but it seems plausible that XXR would have lower overall gastric acid levels over time vs the short acting blast of Percocet every 4-6 hours. Would the gastric acid spikes of Percocet mirror the serum level spikes as depicted in our sales aids?

Not a costly study to conduct and in this uber competitive category, there has to be some clinical (efficacy, tolerabilty, safety) or cost benefits to justify mc plans to cover it and for hcps to prescribe it.

Not clinically signifacand and most docs would not believe the data. Does a slpike in acid levels mean anything?? probably not significant