HCV- Lets have an Honest Discussion


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I hate you people.....You start threads but you don't have the "balls" to actually "say' anything controversial yourself. However, you want people like me to say controversial things. OK! I WILL. I think Todd Putz is doing a good job. Put that in your pipe and smoke it!
 




I hate you people.....You start threads but you don't have the "balls" to actually "say' anything controversial yourself. However, you want people like me to say controversial things. OK! I WILL. I think Todd Putz is doing a good job. Put that in your pipe and smoke it!

you must be joking right?? Putts is the poster child for Big Pharma ineptitude...
 




I will let you start this:

I've seen the data from our investigational drugs, they look good, we just need to hang on and support HIV. I'm excited to be getting the experience and work with a great rep in my HIV partner. This is going to work and we need to get on board, we have a good drug and are respected in the market place. Let's make the best of this, we will need their help when the time comes if that's in the plan. I'm enjoying my time winning friends and enfluencing people.
 








Sir - I do think that your drug is excellent. The problem is you and your colleagues attitude. Its a bit too condescending - I think. Remember that old bible passage: Pride cometh before destruction. I'm not saying that this passage applies to you...but please re-read your comment and please understand how some may interpret this as a little bit "cocky".
 




Sir - I do think that your drug is excellent. The problem is you and your colleagues attitude. Its a bit too condescending - I think. Remember that old bible passage: Pride cometh before destruction. I'm not saying that this passage applies to you...but please re-read your comment and please understand how some may interpret this as a little bit "cocky".

Oh, they are all cocky. And also understand that their NE is training your patients on Pegintron so you need to hook up with her and make sure she knows what she is doing.
 








































Spoke to a couple of investigators in my area - they have had problems with the final analysis of the Phase 2 data. Each have had 2 patients with elevated ALT that they feel were caused by 5172. Both have said that the product is close to being dead. Flares at week 4 in each, all were discontinued but had coding issues so didn't show up in final presentation. Phase 3 except for renal study now on hold until the hepatic safety of 5172 is confirmed from other studies. Both PI told me that best case is that drug is now delayed from starting Phase 3 for 12-18 months. Worst case is that 5172 is done.
 




Spoke to a couple of investigators in my area - they have had problems with the final analysis of the Phase 2 data. Each have had 2 patients with elevated ALT that they feel were caused by 5172. Both have said that the product is close to being dead. Flares at week 4 in each, all were discontinued but had coding issues so didn't show up in final presentation. Phase 3 except for renal study now on hold until the hepatic safety of 5172 is confirmed from other studies. Both PI told me that best case is that drug is now delayed from starting Phase 3 for 12-18 months. Worst case is that 5172 is done.

I doubt this is true. Why would we push forward if there's safety problems?
 




Spoke to a couple of investigators in my area - they have had problems with the final analysis of the Phase 2 data. Each have had 2 patients with elevated ALT that they feel were caused by 5172. Both have said that the product is close to being dead. Flares at week 4 in each, all were discontinued but had coding issues so didn't show up in final presentation. Phase 3 except for renal study now on hold until the hepatic safety of 5172 is confirmed from other studies. Both PI told me that best case is that drug is now delayed from starting Phase 3 for 12-18 months. Worst case is that 5172 is done.

This is a simplistic summary and you don't have all the information you need to assess this topic. Neither do the PI's. Stop the rabid speculation. Phase III trials are scheduled to begin June 2014. The support areas are ramping up for this study - supplies have been made. You should stick to your area of expertise.
 




I doubt this is true. Why would we push forward if there's safety problems?

Ummmm….this is Merck. Have you looked at our recent track record with R&D? Failure after failure after failure. This is about the only drug in the pipeline that looks even remotely valuable to the company. They can't afford NOT to give it a try!
 




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