FDA communication says Zyvox + Antidepressants = lethal

[Anonymous]

Good thing the brand teams informed us of this on today's teleconference. Doh!

http://www.bloomberg.com/news/2011-...e-toxicity-with-antidepressants-fda-says.html

 

[Anonymous]

The Food and Drug Administration warned of a drug interaction between the Pfizer Inc. (PFE) antibiotic Zyvox and many common antidepressants.

The agency issued a drug safety communication Tuesday alerting doctors to a condition called serotonin syndrome in patients being treated with both types of drugs. Serotonin syndrome is caused by high levels of the brain chemical serotonin building up in the brain, which can cause confusion and memory problems and be fatal in some cases.

Most common antidepressants work through the serotonin system of the brain to treat depression and other psychiatric conditions. Zyvox, which is an antibiotic used to treat MRSA and other serious infections, inhibits an enzyme that is involved with the breakdown of serotonin, FDA said.

FDA said Zyvox shouldn't be given to patients who are taking antidepressants but issued recommendations for use of the drug in certain situations where Zyvox needs to be used that include temporarily stopping the use of antidepressants. The instructions for use of the products will be added to Zyvox and antidepressant labels. Zyvox's label already discusses the possibility of the drug interactions.

In a separate drug safety communication issued Tuesday, the FDA warned of a similar interaction between many antidepressants and a drug called methylene blue which is used as a dye and as an emergency treatment of cyanide poisoning.

 

[Anonymous]

Another nail in IS coffin. Good bye and good luck.

 

[Anonymous]

It is not the brand team's fault that they failed to inform us.

Do you not get it? They can't take a shit without getting RC approval. They do nothing without checking with legal first. When the brand team cubicle warriors head home after their 12 hour day, they call RC and ask if they get a little with their spouse. If RC says no, the marketeer heads to the basement and has some scrapple.

The real power in Manhattan and Collegeville rests entirely with the dorks, dweebs and fat ugly chicks that we picked on in high school These goofs are now returning some revenge and they like their power.

"Good Job!"

 

[Anonymous]

It is not the brand team's fault that they failed to inform us.

Do you not get it? They can't take a shit without getting RC approval. They do nothing without checking with legal first. When the brand team cubicle warriors head home after their 12 hour day, they call RC and ask if they get a little with their spouse. If RC says no, the marketeer heads to the basement and has some scrapple.

The real power in Manhattan and Collegeville rests entirely with the dorks, dweebs and fat ugly chicks that we picked on in high school These goofs are now returning some revenge and they like their power.

"Good Job!"

It's all ploy to make sure you are as unsuccessful as one can possibly imagine....ha...revenge of the nerds.

 

[Anonymous]

But us dorky guys and dweeby girls have fun working late and shredding important documents

 

[Anonymous]

This will have no negative impact to zyvox sales. Docs know already and we already tell them. It's nothing.