To run this business profitably and effectively, it takes bright people and they need to get proper experience and professional (as opposed to social) mentoring. Merck is abandoning its experienced base in order to jettison payroll. It is also continuing to do a shit job of developing its new talent, a tendency that was initiated by the present generation of self-centered leaders 20 years ago. Almost all of the new installations that opened during the pharma industry's massive facility expansions of the last 15 years have struggled with establishing technical competence, regardless of the money splashed to build and open them. Vagelos cautioned against expanding the base too fast and thereby diluting the experience base but he was ignored, apparently. A few centers of development excellence and a few strong manufacturing sites is all that could ever be profitably sustained. But low tax zones are tempting to those that don't really appreciate the core business. Moving the industry and its leadership overseas would seem to be a counterproductive thing to do unless, of course, it is a devoid of technical capability as it seems to be right now, right here at home.