Donanemab - uh, oh

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anonymous

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CTAD Alzheimer Congress | 15th Clinical Trials on Alzheimer's Disease

7:50 PM EST (4:50 PM PST)

Clarity AD: A Phase 3 Placebo-Controlled, Double-Blind, Parallel-Group, 18-Month Study Evaluating
Lecanemab in Early Alzheimer's Disease
Chairman: Takeshi Iwatsubo, University of Tokyo - Tokyo (Japan)

Presentation 1: Clarity AD: Clinical Trial Background and Study Design Overview
Michael Irizarry, Eisai Inc. - Nutley, NJ (United States)

Presentation 2: Lecanemab for the Treatment of Early Alzheimer’s Disease: Topline Efficacy Results from Clarity AD
Christopher van Dyck, Yale School of Medicine - New Haven, CT (United States)

Presentation 3: Safety Profile of Lecanemab in Early Alzheimer’s Disease
Marwan Sabbagh, Barrow Neurological Institute - Phoenix, AZ (United States)

Presentation 4: Imaging, Plasma, and CSF Biomarkers Assessments from Clarity AD
Randall J. Bateman, Washington University - St. Louis, MO (United States)

Presentation 5: Context of Clarity AD Results
Sharon Cohen, Toronto Memory Program - Toronto, Ontario (Canada)

Panel Discussion and Q&A
 








anonymous said:
Easy now, just background noise
If this was any concern, FDA would've shut things down already
Click to expand...


It isn’t a big deal. They are old. Patients will die. They die on every drug. The problem with this class of drugs is that the press is relentless. I was at Biogen for the debacle. Hand to God, I hope that for the sake of patients (I’m not usually this sentimental), Lilly fights back and doesn’t f up their launch like Biogen did (i really don’t think it’s possible to do any worse). They are good drugs! The whole “is it clinically meaningful” BS is just that - BS. Look at the scores for CDR-SB in the EARLY stages. A half a point is a pretty damn significant difference.
You are fighting against the dirty underbelly of academia. Plenty of the critics just want their names in the press. Of those vocal adcom turds, only one was a nephrologist, and he doesn’t even treat AD! Plus, some are against these drugs because it will totally screw with their research. If these drugs work, other drug companies will divert dollars to AB mabs vs other MOAs. Current clinical trials will have people dropping out to get on these meds if they become widely accepted, so they will lose money for current trials.
Any news, especially negative news, about these drugs is major click bait. It’s cancel culture at its finest. Even if a doctor is sold, patients read this drivel and get scared.
It’s all about the money - worse than I’ve seen it in 20 years in this industry.
To those of you who take these jobs, my family & I thank you, and I sincerely hope that Lilly’s PR department doesn’t sit on their hands like Biogen’s did.
 




anonymous said:
It isn’t a big deal. They are old. Patients will die. They die on every drug. The problem with this class of drugs is that the press is relentless. I was at Biogen for the debacle. Hand to God, I hope that for the sake of patients (I’m not usually this sentimental), Lilly fights back and doesn’t f up their launch like Biogen did (i really don’t think it’s possible to do any worse). They are good drugs! The whole “is it clinically meaningful” BS is just that - BS. Look at the scores for CDR-SB in the EARLY stages. A half a point is a pretty damn significant difference.
You are fighting against the dirty underbelly of academia. Plenty of the critics just want their names in the press. Of those vocal adcom turds, only one was a nephrologist, and he doesn’t even treat AD! Plus, some are against these drugs because it will totally screw with their research. If these drugs work, other drug companies will divert dollars to AB mabs vs other MOAs. Current clinical trials will have people dropping out to get on these meds if they become widely accepted, so they will lose money for current trials.
Any news, especially negative news, about these drugs is major click bait. It’s cancel culture at its finest. Even if a doctor is sold, patients read this drivel and get scared.
It’s all about the money - worse than I’ve seen it in 20 years in this industry.
To those of you who take these jobs, my family & I thank you, and I sincerely hope that Lilly’s PR department doesn’t sit on their hands like Biogen’s did.
Click to expand...


GTFO dude. The AD drugs are a money grab by companies and Lilly is no different. It’s already been proven that the plaques & tangles theory is BS.

These drugs are subjective & based on a patient with me more problems telling the HCP if they think they have improved lmaooooo. Or better yet they depend on a care giver guessing whether they think the patient has improved and relaying that to the HCP.

Does any AD drug really work? No one knows for sure.

Plus these new drugs are for mild only. Most patients present at moderate by the time they reach the HCP
 




anonymous said:
GTFO dude. The AD drugs are a money grab by companies and Lilly is no different. It’s already been proven that the plaques & tangles theory is BS.

These drugs are subjective & based on a patient with me more problems telling the HCP if they think they have improved lmaooooo. Or better yet they depend on a care giver guessing whether they think the patient has improved and relaying that to the HCP.

Does any AD drug really work? No one knows for sure.

Plus these new drugs are for mild only. Most patients present at moderate by the time they reach the HCP
Click to expand...
Money grab?!? Biogen made so much they scrapped the division after one year. And they made so much money they scrapped the division. Some of your insight is true. Others completely off. Plaques and tangles is a bs theory. No amyloid removal is the bs research. Get your facts straight.
 
















anonymous said:
As former military and the child of a pilot, Southwest needs to get it together

Sounds just as dumb as the bullshit that you typed.
Click to expand...
You are wrong. First of all, the analogy is nonsensical. Second, companies need to stop the nonsense of spending billions on therapeutics that have ZERO chance of working. I wish you all the best. Do you even have a modicum of knowledge of how the public is being misled? Of course not, you privileged, in-bred yuppie moron.
 




anonymous said:
As a former Lilly employee with a parent with Alzheimer's, I wish the company would stop wasting time on this nonsense.
Click to expand...


Let's play "Antibodies for Alzheimers!"

There are so many genetic, dietary, behavior components here... with the exception of an extremely small number of genetic early AD cases. Agree with you completely.

Biogen/FDA pulled a fast one and it's insane to think that an antibody would be appropriate here. It is a colossal systemic failure of our pharma companies and regulatory bodies. Stop this nonsense
 












anonymous said:
Let's play "Antibodies for Alzheimers!"

There are so many genetic, dietary, behavior components here... with the exception of an extremely small number of genetic early AD cases. Agree with you completely.

Biogen/FDA pulled a fast one and it's insane to think that an antibody would be appropriate here. It is a colossal systemic failure of our pharma companies and regulatory bodies. Stop this nonsense
Click to expand...


You are a complete f-ing moron. First of all, the only genetic factor identified...which is showing to be quite f-ing significant...and it is responsible for increasing accumulation of AB!!!

You people don't know a goddamn thing. You are typical Americans who read headlines versus details and hope on any bandwagon that suits your mood. I bet you dumbasses still don't think COVID was a big deal or that masks worked...on the flat earth. Idiots.
 
















anonymous said:
Let's play "Antibodies for Alzheimers!"

There are so many genetic, dietary, behavior components here... with the exception of an extremely small number of genetic early AD cases. Agree with you completely.

Biogen/FDA pulled a fast one and it's insane to think that an antibody would be appropriate here. It is a colossal systemic failure of our pharma companies and regulatory bodies. Stop this nonsense
Click to expand...

eat less food, eat better food, eat early in the day but not at night, exercise 30minutes a day doing something you enjoy that breaks a sweat, have honest relationships and self-honesty, manage stress… There may not be a pill or injection that is a magic bullet.
 




anonymous said:
You are a complete f-ing moron. First of all, the only genetic factor identified...which is showing to be quite f-ing significant...and it is responsible for increasing accumulation of AB!!!

You people don't know a goddamn thing. You are typical Americans who read headlines versus details and hope on any bandwagon that suits your mood. I bet you dumbasses still don't think COVID was a big deal or that masks worked...on the flat earth. Idiots.
Click to expand...

Just what is your job title and background? Would your mother approve of this kind of language?
 








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