Clinical opinion

Anonymous

Guest
I am a physician, long practicing, experienced, well read in research literature, and it’s time we provide everyone with our thoughts. Here are EIGHT REASONS BELVIQ IS PREFERRED FIRST LINE.

Everything else is media hype or misinformed HF/ MM, who could give a flip about real patients.

The sacred Hippocratic Oath all we took upon med school graduation requires us to put our patent's welfare first, balancing risks vs. potential benefits for each.

No one treatment plan fits all. After extensive review and debate among us, almost all of my local colleagues will start with BELVIQ. Why?


1) PATIENT SAFETY: BELVIQ WINS. Belviq has no severe REMS unlike Q. There is no known teratogenic potential of cleft lip or palate defects, and no known risk of amphetamine related morbidity, such as heart attack, cardiac arrhythmias, or strokes.

2) WEIGHT LOSS EFFICACY: EQUIVALENT. Belviq and Qsymia are roughly equivalent at 8% after 12 months in placebo adjusted studies with FDA approved lower Q dosage. Higher Q dosage was NOT approved. Please do not try to fool anyone unless you have really digested the real figures from BLOOM AND BLOSSOM.

3) SIDE EFFECTS: BELVIQ WINS. BELVIQ confers on its users no feelings of nervousness or feeling “wired:” Our patients do not desire this feeling.

4). PATIENT AND PRESCRIBER CONVENIENCE: BELVIQ WINS. Simple Rx, and get it filled at local pharmacy. Qsymia requires labwork, frequent patient visits to doctors, cardiac monitoring, blood pregnancy testing, which will have to be done monthly. Any physician who prescribes Q will have his or her schedule jammed up with Q surveillance, reducing physician availability to others who require evaluation. The patient will have to have their Rx filled at a mail order pharmacy.

5) REDUCTION IN ORAL CONTRACEPTIVE EFFECTIVENESS: BELVIQ WINS. BELVIQ causes no reduction in contraceptive effectiveness. QSYMIA reduces birth control pill effectiveness due to its hepatic topirmamine metabolism. How many unintended pregnancies will occur with female teens taking their mother’s prescriptions? How many will choose to NOT to undergo abortion?

6) DIABETIC BENEFITS: BELVIQ WINS. Due to its 0.9% reduction in hemoglobin a1C levels, and 27% reduction in fasting blood sugar levels, BELVIQ will likely become first line therapy in most Type II diabetics.

7) MEDICO-LEGAL RISKS TO THE PRESCRIBER: BELVIQ WINS. QSYMIA IS TOO DANGEROUS TO BE FIRST LINE.

8) COST TO PATIENT OR THEIR INSURANCE COMPANY: BELVIQ WINS. BELVIQ requires little follow up. On the other hand, someone will have to pay for QSYMIA’s labwork, frequent doctor visits, cardiac monitoring, blood pregnancy testing, and mail order postage many times a year. All this costs money. Qsymia will be MUCH MORE EXPENSIVE to take. Which medication will likely be an approved formulary medication in the future for managed care? It won’t be Qsymia I promise you.
 






I am a physician, long practicing, experienced, well read in research literature, and it’s time we provide everyone with our thoughts. Here are EIGHT REASONS BELVIQ IS PREFERRED FIRST LINE.

Everything else is media hype or misinformed HF/ MM, who could give a flip about real patients.

The sacred Hippocratic Oath all we took upon med school graduation requires us to put our patent's welfare first, balancing risks vs. potential benefits for each.

No one treatment plan fits all. After extensive review and debate among us, almost all of my local colleagues will start with BELVIQ. Why?


1) PATIENT SAFETY: BELVIQ WINS. Belviq has no severe REMS unlike Q. There is no known teratogenic potential of cleft lip or palate defects, and no known risk of amphetamine related morbidity, such as heart attack, cardiac arrhythmias, or strokes.

2) WEIGHT LOSS EFFICACY: EQUIVALENT. Belviq and Qsymia are roughly equivalent at 8% after 12 months in placebo adjusted studies with FDA approved lower Q dosage. Higher Q dosage was NOT approved. Please do not try to fool anyone unless you have really digested the real figures from BLOOM AND BLOSSOM.

3) SIDE EFFECTS: BELVIQ WINS. BELVIQ confers on its users no feelings of nervousness or feeling “wired:” Our patients do not desire this feeling.

4). PATIENT AND PRESCRIBER CONVENIENCE: BELVIQ WINS. Simple Rx, and get it filled at local pharmacy. Qsymia requires labwork, frequent patient visits to doctors, cardiac monitoring, blood pregnancy testing, which will have to be done monthly. Any physician who prescribes Q will have his or her schedule jammed up with Q surveillance, reducing physician availability to others who require evaluation. The patient will have to have their Rx filled at a mail order pharmacy.

5) REDUCTION IN ORAL CONTRACEPTIVE EFFECTIVENESS: BELVIQ WINS. BELVIQ causes no reduction in contraceptive effectiveness. QSYMIA reduces birth control pill effectiveness due to its hepatic topirmamine metabolism. How many unintended pregnancies will occur with female teens taking their mother’s prescriptions? How many will choose to NOT to undergo abortion?

6) DIABETIC BENEFITS: BELVIQ WINS. Due to its 0.9% reduction in hemoglobin a1C levels, and 27% reduction in fasting blood sugar levels, BELVIQ will likely become first line therapy in most Type II diabetics.

7) MEDICO-LEGAL RISKS TO THE PRESCRIBER: BELVIQ WINS. QSYMIA IS TOO DANGEROUS TO BE FIRST LINE.

8) COST TO PATIENT OR THEIR INSURANCE COMPANY: BELVIQ WINS. BELVIQ requires little follow up. On the other hand, someone will have to pay for QSYMIA’s labwork, frequent doctor visits, cardiac monitoring, blood pregnancy testing, and mail order postage many times a year. All this costs money. Qsymia will be MUCH MORE EXPENSIVE to take. Which medication will likely be an approved formulary medication in the future for managed care? It won’t be Qsymia I promise you.


If you WERE an actual physican, I'm sure you would have more important things to do with your time then write out this thesis length clinical opinion. You ARE the Belviq rep, and already you are trying to plant the seed of doubt in the competition. Your verbiage is way to sale-sy for a doc. Spare me. Nice try though with the Jedi mind trick! Relax, you'll get your scripts, but please know that the the Qsymia rep in your territory will as well:)
 






interesting analyses-how many in the Belviq sales force...150 for Vivus this could create a different scenerio with how many MD"s are detailed on the benefits of each medication...
 






Hmmm, looks like you forgot to look at the fda press release on Belviq

"Belviq should not be used during pregnancy. Treatment with Belviq may cause serious side effects, including serotonin syndrome, particularly when taken with certain medicines that increase serotonin levels or activate serotonin receptors. These include, but are not limited to, drugs commonly used to treat depression and migraine. Belviq may also cause disturbances in attention or memory."

There is more to the drugs safety than you seem to want to acknowledge, just giving one example...
here is a link to the press release
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm309993.htm



I am a physician, long practicing, experienced, well read in research literature, and it’s time we provide everyone with our thoughts. Here are EIGHT REASONS BELVIQ IS PREFERRED FIRST LINE.

Everything else is media hype or misinformed HF/ MM, who could give a flip about real patients.

The sacred Hippocratic Oath all we took upon med school graduation requires us to put our patent's welfare first, balancing risks vs. potential benefits for each.

No one treatment plan fits all. After extensive review and debate among us, almost all of my local colleagues will start with BELVIQ. Why?


1) PATIENT SAFETY: BELVIQ WINS. Belviq has no severe REMS unlike Q. There is no known teratogenic potential of cleft lip or palate defects, and no known risk of amphetamine related morbidity, such as heart attack, cardiac arrhythmias, or strokes.

2) WEIGHT LOSS EFFICACY: EQUIVALENT. Belviq and Qsymia are roughly equivalent at 8% after 12 months in placebo adjusted studies with FDA approved lower Q dosage. Higher Q dosage was NOT approved. Please do not try to fool anyone unless you have really digested the real figures from BLOOM AND BLOSSOM.

3) SIDE EFFECTS: BELVIQ WINS. BELVIQ confers on its users no feelings of nervousness or feeling “wired:” Our patients do not desire this feeling.

4). PATIENT AND PRESCRIBER CONVENIENCE: BELVIQ WINS. Simple Rx, and get it filled at local pharmacy. Qsymia requires labwork, frequent patient visits to doctors, cardiac monitoring, blood pregnancy testing, which will have to be done monthly. Any physician who prescribes Q will have his or her schedule jammed up with Q surveillance, reducing physician availability to others who require evaluation. The patient will have to have their Rx filled at a mail order pharmacy.

5) REDUCTION IN ORAL CONTRACEPTIVE EFFECTIVENESS: BELVIQ WINS. BELVIQ causes no reduction in contraceptive effectiveness. QSYMIA reduces birth control pill effectiveness due to its hepatic topirmamine metabolism. How many unintended pregnancies will occur with female teens taking their mother’s prescriptions? How many will choose to NOT to undergo abortion?

6) DIABETIC BENEFITS: BELVIQ WINS. Due to its 0.9% reduction in hemoglobin a1C levels, and 27% reduction in fasting blood sugar levels, BELVIQ will likely become first line therapy in most Type II diabetics.

7) MEDICO-LEGAL RISKS TO THE PRESCRIBER: BELVIQ WINS. QSYMIA IS TOO DANGEROUS TO BE FIRST LINE.

8) COST TO PATIENT OR THEIR INSURANCE COMPANY: BELVIQ WINS. BELVIQ requires little follow up. On the other hand, someone will have to pay for QSYMIA’s labwork, frequent doctor visits, cardiac monitoring, blood pregnancy testing, and mail order postage many times a year. All this costs money. Qsymia will be MUCH MORE EXPENSIVE to take. Which medication will likely be an approved formulary medication in the future for managed care? It won’t be Qsymia I promise you.
 






Hmmm, looks like you forgot to look at the fda press release on Belviq

"Belviq should not be used during pregnancy. Treatment with Belviq may cause serious side effects, including serotonin syndrome, particularly when taken with certain medicines that increase serotonin levels or activate serotonin receptors. These include, but are not limited to, drugs commonly used to treat depression and migraine. Belviq may also cause disturbances in attention or memory."

There is more to the drugs safety than you seem to want to acknowledge, just giving one example...
here is a link to the press release
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm309993.htm

CAN WE GET A "LIKE" button???
 






Hey OB, you better read the PI and clinicals. Nice summary on the 8 reasons why, but why would you wait that long, pay that much, and take any risk for minimal efficacy? See you soon.
 






"The sacred Hippocratic Oath all we took upon med school graduation requires us to put our patent's welfare first, balancing risks vs. potential benefits for each." Really. Really!?! REALLY!?!?!?!? Is that why you take bonus dollars from the insurance companies to rx generics when you know the brand name meds are more efficatious?? Why would you rx a generic for, lets say, hypertension, when you know there may only be 80% of the active molecule in the generic the patient receives - so they're hypertensive again. And you have to say, "Gee, Patient X, I guess this isn't working. Lets titrate or change meds. That ought to do it." Hippocratic Oath MY ASS. Bow down to your BlueCross/Blue Shield master.
 






"The sacred Hippocratic Oath all we took upon med school graduation requires us to put our patent's welfare first, balancing risks vs. potential benefits for each." Really. Really!?! REALLY!?!?!?!? Is that why you take bonus dollars from the insurance companies to rx generics when you know the brand name meds are more efficatious?? Why would you rx a generic for, lets say, hypertension, when you know there may only be 80% of the active molecule in the generic the patient receives - so they're hypertensive again. And you have to say, "Gee, Patient X, I guess this isn't working. Lets titrate or change meds. That ought to do it." Hippocratic Oath MY ASS. Bow down to your BlueCross/Blue Shield master.

So true! One of the best posts on CP in awhile! Drug rep from completely different industry, but it is all the same! Why write generic if you are putting the patient first? Which part of
The patient; clinical benefit or their bank account?
 






May the hottest rep win. Isn't that how it always works? A little skin, touch on the shoulder or a smile is something that perks up the day of many lonely and overworked physicians. It's one of the few ways to see a spring in the step or bulge in the crotch of a doctor.
 






There is a 0% chance you are a physician and a 100% chance you are a drug rep trying to sell your dog of a drug.

I thought about rebutting every single one of your "8 Reasons" to call you out on your obvious drug rep brain wash, fresh out of training. I'll let you learn the hard way when you look foolish in the field.

I will throw you a few bones, however. I'd look at your OWN drug's Warnings, Precautions and Adverse Events before you start touting how your "patients" don't want those feelings.

I'd also not get too excited about the HbA1C drop, considering it was only half of one percent more than placebo in patients who's numbers were very high to begin with.

Regarding the blood sugar decreases that you are excited about: that's pretty easy to do when your drug is causing Hypoglycemia. I'm pretty sure that's also something "your" patients don't want.

Regarding patient and prescriber convenience: your drug is still twice a day vs. your competition's once a day. It shouldn't be a big deal, but it is.

Contraceptive ineffectiveness and the cleft lip/palate with your competition, etc: Non-issues because it's not true (possible spotting only, not decreased effectiveness) and Q is not supposed to be used if you're pregnant. No one is going to prescribe Q for a pregnant woman with that information on the label. I wouldn't be touting that advantage to your doctors....err your "patients". Sorry.

Cost, Insurance, First Line etc. You'll never compete with generic combinations, regardless of indications and FDA approved treatments. PBM's and pharmacies will ensure that.

Hope this helps. Don't want you to lose ALL credibility with your docs (patients. lol), if you haven't already. Good luck. You, and your competition, have a tough road ahead.

I am a physician, long practicing, experienced, well read in research literature, and it’s time we provide everyone with our thoughts. Here are EIGHT REASONS BELVIQ IS PREFERRED FIRST LINE.

Everything else is media hype or misinformed HF/ MM, who could give a flip about real patients.

The sacred Hippocratic Oath all we took upon med school graduation requires us to put our patent's welfare first, balancing risks vs. potential benefits for each.

No one treatment plan fits all. After extensive review and debate among us, almost all of my local colleagues will start with BELVIQ. Why?


1) PATIENT SAFETY: BELVIQ WINS. Belviq has no severe REMS unlike Q. There is no known teratogenic potential of cleft lip or palate defects, and no known risk of amphetamine related morbidity, such as heart attack, cardiac arrhythmias, or strokes.

2) WEIGHT LOSS EFFICACY: EQUIVALENT. Belviq and Qsymia are roughly equivalent at 8% after 12 months in placebo adjusted studies with FDA approved lower Q dosage. Higher Q dosage was NOT approved. Please do not try to fool anyone unless you have really digested the real figures from BLOOM AND BLOSSOM.

3) SIDE EFFECTS: BELVIQ WINS. BELVIQ confers on its users no feelings of nervousness or feeling “wired:” Our patients do not desire this feeling.

4). PATIENT AND PRESCRIBER CONVENIENCE: BELVIQ WINS. Simple Rx, and get it filled at local pharmacy. Qsymia requires labwork, frequent patient visits to doctors, cardiac monitoring, blood pregnancy testing, which will have to be done monthly. Any physician who prescribes Q will have his or her schedule jammed up with Q surveillance, reducing physician availability to others who require evaluation. The patient will have to have their Rx filled at a mail order pharmacy.

5) REDUCTION IN ORAL CONTRACEPTIVE EFFECTIVENESS: BELVIQ WINS. BELVIQ causes no reduction in contraceptive effectiveness. QSYMIA reduces birth control pill effectiveness due to its hepatic topirmamine metabolism. How many unintended pregnancies will occur with female teens taking their mother’s prescriptions? How many will choose to NOT to undergo abortion?

6) DIABETIC BENEFITS: BELVIQ WINS. Due to its 0.9% reduction in hemoglobin a1C levels, and 27% reduction in fasting blood sugar levels, BELVIQ will likely become first line therapy in most Type II diabetics.

7) MEDICO-LEGAL RISKS TO THE PRESCRIBER: BELVIQ WINS. QSYMIA IS TOO DANGEROUS TO BE FIRST LINE.

8) COST TO PATIENT OR THEIR INSURANCE COMPANY: BELVIQ WINS. BELVIQ requires little follow up. On the other hand, someone will have to pay for QSYMIA’s labwork, frequent doctor visits, cardiac monitoring, blood pregnancy testing, and mail order postage many times a year. All this costs money. Qsymia will be MUCH MORE EXPENSIVE to take. Which medication will likely be an approved formulary medication in the future for managed care? It won’t be Qsymia I promise you.
 






There is a 0% chance you are a physician and a 100% chance you are a drug rep trying to sell your dog of a drug.

I thought about rebutting every single one of your "8 Reasons" to call you out on your obvious drug rep brain wash, fresh out of training. I'll let you learn the hard way when you look foolish in the field.

I will throw you a few bones, however. I'd look at your OWN drug's Warnings, Precautions and Adverse Events before you start touting how your "patients" don't want those feelings.

I'd also not get too excited about the HbA1C drop, considering it was only half of one percent more than placebo in patients who's numbers were very high to begin with.

Regarding the blood sugar decreases that you are excited about: that's pretty easy to do when your drug is causing Hypoglycemia. I'm pretty sure that's also something "your" patients don't want.

Regarding patient and prescriber convenience: your drug is still twice a day vs. your competition's once a day. It shouldn't be a big deal, but it is.

Contraceptive ineffectiveness and the cleft lip/palate with your competition, etc: Non-issues because it's not true (possible spotting only, not decreased effectiveness) and Q is not supposed to be used if you're pregnant. No one is going to prescribe Q for a pregnant woman with that information on the label. I wouldn't be touting that advantage to your doctors....err your "patients". Sorry.

Cost, Insurance, First Line etc. You'll never compete with generic combinations, regardless of indications and FDA approved treatments. PBM's and pharmacies will ensure that.

Hope this helps. Don't want you to lose ALL credibility with your docs (patients. lol), if you haven't already. Good luck. You, and your competition, have a tough road ahead.

Lol. It does crack me up when posters try to claim they are physicians and then spew the company's talking points. :)
 






It is nice to know that I can get these new weight loss drugs .... $4...with generics! So Excited and so is my doctor....Can you say $4....$4 can you say! Have fun bashing...you all are fools! Keep drinking the cool-aid!
 






CAN WE GET A "LIKE" button???

If I was the Belviq rep - I Would BEG- Maybe even PAY you to go into your offices and talk about this. Please do it! The whole Serotonin Syndrome has sooooo much clinical relevance and has been such a HUGE issue between triptans and Anti-Depressants in the past.. You REALLY need to make a BIG issue about the Serotonin Syndrome with your customers...spend all your time talking about this HUG ISSUES----PLEASE
 






If I was the Belviq rep - I Would BEG- Maybe even PAY you to go into your offices and talk about this. Please do it! The whole Serotonin Syndrome has sooooo much clinical relevance and has been such a HUGE issue between triptans and Anti-Depressants in the past.. You REALLY need to make a BIG issue about the Serotonin Syndrome with your customers...spend all your time talking about this HUG ISSUES----PLEASE

Qsymia has no interactions with either - good to remember with pcps.