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- small testicles (hypogonadism) – Regeneron males with always have small testicles from puberty
- lack of facial, pubic and underarm hair
- poor muscle development
- breast tissue development (gynaecomastia)
- unexplained weight gain, especially on the stomach or trunk
- tiredness and fatigue
- small penis
- disproportionately long arms and legs compared to the length of the body
- taller than average height
- poor concentration
- single crease in the palm (simian crease)
- difficulties with sexual functioning
- speech and learning difficulties – in some cases this can lead to behavioural problems
- sadness, lowered mood or depression.