Biodegradeable Magnesium Stent with mechanical advantages of metal stents

Anonymous

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The new device is made of a biodegradable magnesium alloy combined with a slow release drug and is intended to open vessels and to keep them from re-clogging, while avoiding the longer term disadvantages associated with permanent metal stents.

DREAMS technology is revolutionary in that it combines for the first time, the acute mechanical advantages of a metallic stent with an anti-proliferative drug, plus a reliable degradation profile that allows the vessel to slowly return to its natural physiology.
 












Does Biotronik have stent reps in the US ??

The Bare Metal Stent isn't even close, and the conversation about BioAbsorbable usually points to 7 or 8 more years to market. Bio doesn't have a stent field force for these future products, and they barely have a field force for their EXISTING CRM business.
 






Biotroniks issue is not product, its leadership and management. They have as good or better product than any other CRM company worldwide. If you disagree, then you are a fool. Their leadership and managements vision is myopic at best. They always go for the cheap fix and think in get rich quick mentalities. They struck peverbial gold in Vegas-SoCal initially and thought they could replicate it in the PNW, MW, NorCal with disasterous results that will take years to heal. The rest of the country is similar in thinking but a different structure. They continue to pursue a business model that consists of luring tenured reps with a few established relationships who follow, but usually as much or more baggage. Short term bump but long term dwindling of base business. Sort of like chasing the tail linerarly with no vision of progress. So much time is spent putting out fires, issues w independant boondoggles that progress cannot be achieved. They also support the business with strategies of training sites and clinical studies offered as inducements.

As a competitor, I would do my best to support their poor business strategy by offering as little resistance as posible to their hiring practices by "stealing" moderately sucessful reps looking for a cash grab. Perfect example is in Long Island. Essentially a purge of stagnent talent which allows STJ to progress. Bio will never succeed unless major leadership changes from the top down as well as sales managers who actually hold indpendants accountable for illegal sales practices.

If similar tactics are engaged for the creation of a coronary sales force, no matter how good the product is, they will never be a true market leader. Hospitals will never allign with them on dual vendor contracts either. Not to mention the whole "investigation" either. It will not be cheap and they wont be able to buy their way out of it as the big dogs have in the past.
 












Biotroniks issue is not product, its leadership and management. They have as good or better product than any other CRM company worldwide. If you disagree, then you are a fool. Their leadership and managements vision is myopic at best. They always go for the cheap fix and think in get rich quick mentalities. They struck peverbial gold in Vegas-SoCal initially and thought they could replicate it in the PNW, MW, NorCal with disasterous results that will take years to heal. The rest of the country is similar in thinking but a different structure. They continue to pursue a business model that consists of luring tenured reps with a few established relationships who follow, but usually as much or more baggage. Short term bump but long term dwindling of base business. Sort of like chasing the tail linerarly with no vision of progress. So much time is spent putting out fires, issues w independant boondoggles that progress cannot be achieved. They also support the business with strategies of training sites and clinical studies offered as inducements.

As a competitor, I would do my best to support their poor business strategy by offering as little resistance as posible to their hiring practices by "stealing" moderately sucessful reps looking for a cash grab. Perfect example is in Long Island. Essentially a purge of stagnent talent which allows STJ to progress. Bio will never succeed unless major leadership changes from the top down as well as sales managers who actually hold indpendants accountable for illegal sales practices.

If similar tactics are engaged for the creation of a coronary sales force, no matter how good the product is, they will never be a true market leader. Hospitals will never allign with them on dual vendor contracts either. Not to mention the whole "investigation" either. It will not be cheap and they wont be able to buy their way out of it as the big dogs have in the past.

"Hospitals will never allign (sic) with them on dual vendor contracts either."

I disagree. First, because I am in such an agreement. No matter how many people the Big 3 RIFF,they will never compete with BIO on price, and as you point out in your first paragraph - BIO offers a quality product at that price.

I do agree that they will never be a market leader, but at their commission rates - you don't have to be to make a comfortable living.

Leadership woes are everywhere. Starks is an idiot. Omar is going to 'Six Sigma' every aspect of service out of CRM. And Boston...well...whatever.
 






they been hawking this since 1995, without making one to be implanted in the US market; if true to form you guys have another 15 years til they can bring to market, if there is still a market....after all they missed the biV market by about 15 billion in sales....
 






they been hawking this since 1995, without making one to be implanted in the US market; if true to form you guys have another 15 years til they can bring to market, if there is still a market....after all they missed the biV market by about 15 billion in sales....

Late 2006 when they got CRT approval. So at least 15 billion
 
























The new device is made of a biodegradable magnesium alloy combined with a slow release drug and is intended to open vessels and to keep them from re-clogging, while avoiding the longer term disadvantages associated with permanent metal stents.

DREAMS technology is revolutionary in that it combines for the first time, the acute mechanical advantages of a metallic stent with an anti-proliferative drug, plus a reliable degradation profile that allows the vessel to slowly return to its natural physiology.

Send me the link to 2 multi-center, single-blind, randomized trials comparing the biodegadeable magnesium to DES or bare metal stents published in a peer reviewed cardiology journal (preferably English) .

Better yet : you send me the link to one such study, then we`ll talk.
 


















Are they going to give stents to the pacer reps to sell?

That will be a question for whoever is in charge 7 years from now. BIO can't get anything through the FDA Approval process (how long have they been trying to get their MRI Conditional devices in to the US?)

Moreover, BIO has to start with a BareMetal Product, before the absorbable...all this is years away.

If things are the same then, suspect they will coax some VI talent away with obscene guarantees in the bigger markets, and then let the CRM guys in the smaller markets take a shot at selling to their onesies and twosies.
 






Given abbott is arguably a year behind schedule and is slated for a first quarter 2015 launch of its BVS? Biotronik is not that far behind.

Also, there is no guarantee that any stent that completely absorbs is going to work long term so abbott being in the US market by early 2015 is best case scenario.

If the stent is not expanded like the current DES is now(stenting for dummies), how can you assure its well apposed if the material does not expand like the current alloys do,

Bottom line, there are a ton of factors. Lastly, Abbott needs to put the pie down if it thinks it can get the DES market back to 2500 to 3k per stent, why? they are only going to be able to show "non inferiority" unlike the original Cypher trial that showed a huge reduction in restenosis.

Given the cost cutting going on, nno way are hospitals going to pay a 50-100% premium for a product that is "sexy" but is not superior in terms of outcomes
 






So Biotronik is how far behind in stents and drug eluting balloons in terms of clinical trials?

For the contrarians, can you explain this job posting?

ttp://www.biotronik.com/wps/wcm/connect/en_us_web/biotronik/careers/
 






So Biotronik is how far behind in stents and drug eluting balloons in terms of clinical trials?

For the contrarians, can you explain this job posting?

ttp://www.biotronik.com/wps/wcm/connect/en_us_web/biotronik/careers/

Well, the contrarians may need a little help to see the point you are trying to make since your link will take them to the start page for Biotronik Careers. I SUSPECT you are trying to point them to Job #1938 Field Vascular Intervention Specialist.

I can understand why you would prop this up as evidence that a Biotronik VI prooduct is imminent, but really this is just a posting for someone to oversee clinical trials. One of the lesser discussed drawbacks to being at Biotronik is that due to a few factors, things just don't make it throught the pipeline very quick.

Case-in-point, MRI Conditional devices....Europe has BIO ICDs and Brady MRI Options, but the folks at the FDA could care less, and this is with a product line that BIO is already actively implanting in the US...interventional products from BIO are completely unheard of in the US, so isn't it reasonable to believe that BIO VI products trying to break in to this market are going to languish longer than the CRM stuff that already has SOME (not much) acceptance among the implanting community?

And even if BIO does get it out there, look at what is happening to the VI market anyway? Based onwhat we are hearing, bioabsorbable PROBABLY isn't going to be THAT much better than BMS, and if it is not then you can expect that the ASP for BioAbsorbable will be inextricably linked to BMS. You may get some upcharge, but if there's no clear cut therapeutic benefit....


It's a bummer....but there's just no indication (including your link to Job 1938) that BIO is close to a VI offering. My guess-timate is 3 years for a BMS. Based on how that data goes, maybe the FDA will permit BIO to go to trial with Bioabsorbable 5 years from now.
 






Hey I have an idea you stick with the company that is valued at less than a 1/4 of what the purchase price of GDT and has been losing mkt share every year in CRM since 2006 and just now came out with a wireless pacer when BIO has had since 2001, and still is wireless with no device approved to monitor it...

I will stick with the one who has been slow and steadily gaining mkt share for the past 10 years and has new products being introduced in the vascular division even if they are equally as effective as DESs you know they will take off b/c interventionalists will be all over a new class of products that neither BSX or MDT or ABBOT have been able to deliver.

You stay right where you at and let me know how that works out for ya!
 






Given Abbott's absorb BVS is rumored to still be 6-9 months away from starting its US trial, I think Biotronik and its system would be pretty close to Abbott's BVS being approved at "3 years" in terms of US approval

no? Normally, it takes 18-24 months POST start date of a trial to get approval(or so I am told)