Amitiza remains resilient to Linzess threat

[Anonymous]

Amitiza remains resilient to Linzess threat
Commercialised by US partner, Takeda, with 18-23% royalties payable to Sucampo, prescriptions and sales of Amitiza in the US continue to grow and appear largely unaffected by the introduction of Ironwood/Forest’s Linzess. Despite being priced at a 14% discount to Amitiza ($7.10 vs $8.23) and supported by a massive promotional campaign, so far Linzess has not had a direct impact on Amitiza, instead helping to grow the market for the use of Rx drugs for constipation disorders by attracting new patients and those previously using OTC laxatives.

 

[Anonymous]

ha my territory hasnt generated a nrx for am. in months

 

[Anonymous]

Many people are not aware that Ironwoods drug is derived from a bacterial endotoxin while Synergy's drug is just a peptide copy of the hormone Uroguanylin. When you look at the drugs Synergy's drug much more closely resembles Uroguanylin, the hormone they both want to mimic that triggers fluid release in the intestine. This is why analysts think SGYP drug will be best in class. Here is an excerpt from Aegis analyst Raghuram Selvaraju's research report:

"Synergy’s patent estate covers the natural hormone sequence and related peptides.
Ironwood accordingly had to resort to patenting the “ST” peptides derived from bacterial
endotoxin, which have substantial homology with the uroguanylin sequence but are not
identical."

this is why Ironwood company name used to be Microbia. They took the bacterial endotoxin that causes travelers diarrhea and turned it into their drug....

 

[Anonymous]

Many people are not aware that Ironwoods drug is derived from a bacterial endotoxin while Synergy's drug is just a peptide copy of the hormone Uroguanylin. When you look at the drugs Synergy's drug much more closely resembles Uroguanylin, the hormone they both want to mimic that triggers fluid release in the intestine. This is why analysts think SGYP drug will be best in class. Here is an excerpt from Aegis analyst Raghuram Selvaraju's research report:

"Synergy’s patent estate covers the natural hormone sequence and related peptides.
Ironwood accordingly had to resort to patenting the “ST” peptides derived from bacterial
endotoxin, which have substantial homology with the uroguanylin sequence but are not
identical."

this is why Ironwood company name used to be Microbia. They took the bacterial endotoxin that causes travelers diarrhea and turned it into their drug....

Which is why no big pharma company has made an offer to partner with the best in class drug? Or maybe the big dogs realize that SGYPs patent on plecanatide isn't rock solid and could be challenged.

 

[Anonymous]

I Love Linzess. Amatiza stopped working for me after 6 weeks. Linzess works great for me but I do have to use it off label. The diarrhea is tremendous. So when I bloat up and haven't gone for four days, I take one when I get home and don't have to leave the house. Within an hour I'm running to the bathroom. My abdomen goes entirely down and I empty up real good. Sometimes I have movements for several days and I'm happy until I Back up again. So for me using it this way works out good. Losing the bloating and enlarged abdomen is such a relief.

 

[Anonymous]

I Love Linzess. Amatiza stopped working for me after 6 weeks. Linzess works great for me but I do have to use it off label. The diarrhea is tremendous. So when I bloat up and haven't gone for four days, I take one when I get home and don't have to leave the house. Within an hour I'm running to the bathroom. My abdomen goes entirely down and I empty up real good. Sometimes I have movements for several days and I'm happy until I Back up again. So for me using it this way works out good. Losing the bloating and enlarged abdomen is such a relief.

The problem is, your electrolytes are going out of whack every time you have the severe diarrhea that Linzess causes. Electrolyte imbalances lead directly to heart attacks. Hope you don't have one!

 

[Anonymous]

Omg have people had heart attacks? I drink plenty of water. Now you are scaring me. I read the pi and it states that if you get severe diarrhea to stop it. That's why I don't take it every day.

 

[Anonymous]

Yikes I'm going to google more on this. If that's the case I'm stopping it. Pitty we need a good drug for IBS. Metamucil and other stuff just give me gas and make me more bloated. . Thanks for the advice. I'm a rep as well but for another company and a dufferent specialty.