Bristol-Myers Squibb's Opdivo Misses Primary Endpoint in Ph III Study in Small Cell Lung Cancer

Bristol-Myers Squibb Company (NYSE:BMY) announced on 8/12/18 topline results from the Phase 3 CheckMate -331 study evaluating Opdivo (nivolumab) versus the current standard of care, topotecan or amrubicin (where approved), in patients with small cell lung cancer (SCLC) who relapsed following platinum-based chemotherapy. The study did not meet its primary endpoint of overall survival (OS) with Opdivo versus chemotherapy. The safety profile of Opdivo in this trial was consistent with that observed in previously reported monotherapy studies involving patients with SCLC.