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<p>[QUOTE="Anonymous, post: 5151008"]Several other studies have been done with lurasidone in addition to the four studies that were submitted to the FDA—some published, most unpublished. One six-week trial of lurasidone 20 mg, 40 mg, and 80 mg was a failure, showing no difference from placebo. Another three-week trial of lurasidone at 120 mg showed similar efficacy to ziprasidone 80 mg twice daily (Cucchiaro J et al, Schizophr Bull 2009;35(suppl 1):342–343).</p><p><br /></p><p>An unpublished one-year open-label study of 182 patients gives us a sense of the long term tolerability (or lack thereof ) of lurasidone. These patients were taking an average dose of 71 mg, and while most patients improved, the discontinuation rate was 56% over the course of the year—23% because of adverse effects, and 29% for lack of efficacy. Common side effects included serum prolactin increase (19%), and insomnia (18%), with EPS in 27% of patients. However, patients lost 3.3 pounds on average, and had small, nonsignificant decreases in cholesterol, triglycerides, and prolactin levels along with a nonsignificant increase in fasting glucose (Ogo HM et al, poster presented at: International Congress on Schizophrenia Research, 2011, Colorado Springs, CO).[/QUOTE]</p><p><br /></p>
[QUOTE="Anonymous, post: 5151008"]Several other studies have been done with lurasidone in addition to the four studies that were submitted to the FDA—some published, most unpublished. One six-week trial of lurasidone 20 mg, 40 mg, and 80 mg was a failure, showing no difference from placebo. Another three-week trial of lurasidone at 120 mg showed similar efficacy to ziprasidone 80 mg twice daily (Cucchiaro J et al, Schizophr Bull 2009;35(suppl 1):342–343). An unpublished one-year open-label study of 182 patients gives us a sense of the long term tolerability (or lack thereof ) of lurasidone. These patients were taking an average dose of 71 mg, and while most patients improved, the discontinuation rate was 56% over the course of the year—23% because of adverse effects, and 29% for lack of efficacy. Common side effects included serum prolactin increase (19%), and insomnia (18%), with EPS in 27% of patients. However, patients lost 3.3 pounds on average, and had small, nonsignificant decreases in cholesterol, triglycerides, and prolactin levels along with a nonsignificant increase in fasting glucose (Ogo HM et al, poster presented at: International Congress on Schizophrenia Research, 2011, Colorado Springs, CO).[/QUOTE]
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Cafepharma Message Boards | Pharma Sales, Device Sales, Lab Sales
Home
Forums
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Pharma/Biotech Companies
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Sunovion
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New Contest!
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Cafepharma Message Boards | Pharma Sales, Device Sales, Lab Sales
Home
Forums
>
Pharma/Biotech Companies
>
Sunovion
>
New Contest!
>