Protagonist posts phase 2 hormone replacement data, pitching for lead role in genetic iron overload disease

Protagonist Therapeutics wants to take the lead in a genetic iron disease, delivering midphase data on a hormone replacement therapy it envisages offering an alternative to blood draws.

Rusfertide is Protagonist’s attempt to improve on the druglike properties of the hormone hepcidin to alter the regulation of iron homeostasis. In people with hereditary hemochromatosis, who absorb too much iron from food, the mechanism of action could enable physicians to stop excessive iron accumulation—and the negative outcomes it causes—without relying solely on blood draws.