Ex-AbbVie partner Principia posts encouraging PhII results for its BTK-inhibitor

Ex-AbbVie partner Principia posts encouraging PhII results for its BTK-inhibitor

Source: 
Endpoints
snippet: 

Months after their breakup with high-profile partner AbbVie, Principia announced positive preliminary results from the second half of a Phase II trial on their lead drug.

The San Francisco biotech announced data from part B of its Phase II open-label trial testing the BTK inhibitor PRN1008 on patients with pemphigus vulgaris, a rare autoimmune disease affecting the skin and mucous membranes. Of 15 enrolled patients, 6 achieved complete responses and 4 remain on the therapy.