CDC warns of rebounding symptoms after Paxlovid

The CDC issued a warning May 24 that a rebound in COVID-19 symptoms can occur after patients take the antiviral medication Paxlovid.

In some patients who completed a five-day course of Paxlovid, illness has been reported to reoccur between two and eight days after initial recovery from COVID-19. It's characterized by a recurrence of symptoms or a new positive viral test after having tested negative. A brief return of symptoms may be part of the natural history of the virus in some patients, independent of Paxlovid treatment and regardless of vaccination status, according to the alert.