In retrospect, would you say the acquisition of Sirtus for $720 Million was reasonabl

In 2010, GSK dropped Sirtris' main drug candidate, a potential cancer drug based on resveratrol, a compound found in red wine. Is that the end of the story, or can we expect big things from this investement?

 

Re: In retrospect, would you say the acquisition of Sirtus for $720 Million was reaso

The science turned out to be weak, if not bogus. The only thing it seems to do is inhibit the effects of exercise on physical fitness. In other words it slows down any fitness gains when you work out.

 

Re: In retrospect, would you say the acquisition of Sirtus for $720 Million was reaso

The due diligence team(s) advised against doing this deal. It was done anyway. It was cash-money thrown down the cesspit.

 

Re: In retrospect, would you say the acquisition of Sirtus for $720 Million was reaso

The Scientists at GSK told management the compounds were sh*t during due diligence. GSK's management (Moncef Slaoui & Patrick Vallance) ignored their internal scientists and bought the company anyway (for too much money even if the compounds were real). This is part of Moncef's overall strategy of trusting external scientists more than internal ones (just look where they are investing). The blame lies squarely at Moncef's feet for this debacle.

 

Re: In retrospect, would you say the acquisition of Sirtus for $720 Million was reaso

Moncef decided that external innovation was the 'answer' (in fact this is the line that Moncef sold the board to win his job) and proceeded to ignore all internal concerns about quality/validity during due diligence - painting any dissenters with the "not invented here" brush - leading to the current situation. Not trusting (and insisting) that your own scientists to be as good as external is a self-fulfilling nightmare.

 

Re: In retrospect, would you say the acquisition of Sirtus for $720 Million was reaso

As a former Glaxo, GW and finally GSK scientist, who thought Tachi Yamada was an idiot, I was soon begging the the 'Good Old days" once Moncef and Patrick came along. Their stupidity was only matched by their arrogance and ego.

 

Re: In retrospect, would you say the acquisition of Sirtus for $720 Million was reaso

Sirtris is just one of their stupid moves and came at the same time they kicked a number of their excellent scientists in the ass and out of GSK, myself included. Both of these jokers aren't fit to run a corner drug store let alone what USED to be a great company. YES, we told both Moncef and Patrick that Sirtris had NOTHING but NO, they knew better! Morons....

 

Re: In retrospect, would you say the acquisition of Sirtus for $720 Million was reaso

Now we see the motive behind your posts. You got canned and now you want to lash out at those that kicked you out. If we look at history, the old pipeline turned out to be trash. Moncef was a key player in getting the pipeline back on track. Everyone can argue as to whatbthey think the potential is for the new products coming out, but we can clearly see that products are now actually moving along the development path and getting approved. The fact remains that people like this poster needed to be kicked out a long time ago as they produced nothing.

 

Re: In retrospect, would you say the acquisition of Sirtus for $720 Million was reaso

GSK scientists had data which refuted the Sirtris claims yet they were ignored by management. GSK was well aware that artifacts of the assay were the only hits coming from screens. Moncef and Patrick made an idiotic purchase because they have no experience in drug discovery and ignored the people who had decades of experience. This is the same story with Elesclomol, it was purchased despite the internal GSK scientists saying it was shit. It seemed like the head of Oncology CEDD was fired because he dared question their purchase of Elesclomol. When will Witty wake up and replace Moncef? Just because JP put Moncef in place doesn't mean you have to keep him Witty. Wake up and grow some balls.

 

Re: In retrospect, would you say the acquisition of Sirtus for $720 Million was reaso

Give it up. Just because you got canned doesn't mean Moncef needs to go. In fact, that is a good reason keep him. We need people that can clean out the dead wood.

 

Re: In retrospect, would you say the acquisition of Sirtus for $720 Million was reaso

Exactly what pipeline are you talking about Moncef?

 

Re: In retrospect, would you say the acquisition of Sirtus for $720 Million was reaso

I still work at GSK. Moncef is a vacuous disaster. Defending him is ludicrous.

 

Re: In retrospect, would you say the acquisition of Sirtus for $720 Million was reaso

Agree.

 

Re: In retrospect, would you say the acquisition of Sirtus for $720 Million was reaso

So little drug development experience from Moncef and Patrick Vallance -- GSK enzymologists pretty much did the Amgen experiments while running an internal program but were ignored during due diligence. While Moncef & Patrick may have PhD's, neither has any small molecule drug discovery experience and actual knowledge of drug discovery (much less having successfully done it) was/is fatal to your career at GSK with these two in charge - unless you are willing to pucker up & agree with them. Personally, I wouldn't follow them out of a burning building.

 

Re: In retrospect, would you say the acquisition of Sirtus for $720 Million was reaso

Moncef is petrified wood. But his wood is well attended to.

 

Re: In retrospect, would you say the acquisition of Sirtus for $720 Million was reaso

Moncefalopod is underqualified to run a souvlaki stand in Syria.

 

Re: In retrospect, would you say the acquisition of Sirtus for $720 Million was reaso

He slides about RTP, crying out: "MOISTURE! GIVE ME MOISTURE!!" until his attendants water him.

 

Re: In retrospect, would you say the acquisition of Sirtus for $720 Million was reaso

We get it. You are pissed off at Moncef for getting fired. No need to make a dozen posts about him. Go get another job and get over it.

 

Re: In retrospect, would you say the acquisition of Sirtus for $720 Million was reaso

I didn't get fired. I still work for the fool.

 

Re: In retrospect, would you say the acquisition of Sirtus for $720 Million was reaso

Also Vaccines. Not a clue how to develop them.