Does Linzess restore tight junctions like Amitiza?

Discussion in 'Takeda' started by Anonymous, Apr 4, 2013 at 8:55 PM.

  1. Anonymous

    Anonymous Guest

    My friend is a doc and gave me some samples of Linzess. He said it will restore my tight junctions and help my IBS. I don't even know what tight junctions are, so I googled it and one of the search results brought me to this site. I tried Amitiza a few years ago and felt like it didn't work very well, maybe it didn't restore the tight junctions or maybe I wasn't on it long enough. I heard you guys have a new drug for IBS, I don't feel like I'm getting good feedback from the IBS chat boards. I'm hoping someone from the site for pharmaceutical sales professionals can give me some insight.

    Thanks
     
  2. Anonymous

    Anonymous Guest

    NO
     
  3. Anonymous

    Anonymous Guest

    TROLL
     
  4. Anonymous

    Anonymous Guest

    Yes, Linzess does restore tight junctions. In medicine, we call this a class effect. For example, only certain PPI's have indications to treat NSAID induced ulcers. Based on evidence drug makers produced, clinicians can usually conclude other drugs within the same class will give you the same result. Insurance companies also agree. The same could be said for ARB's and CHF. Linzess and Amitiza are both chloride channel activators. If Amitiza has produced the evidence that you can restore tight junctions by dispensing chloride ions then Linzess will give you the same effect too.
     
  5. Anonymous

    Anonymous Guest

    No, only Amitiza restores tight junctions. You may want to have your doctor friend switch you over to Amitiza. Be aware that Linzess has a black box warning because it killed mice due to causing an electrolyte imbalance as a result of severe diarrhea. Their company buried the data on file and it's only a matter of time before the issue begins showing up in the general population. Besides, why would you want to pay 3 times the co-pay when you can get Amitiza?
     
  6. Anonymous

    Anonymous Guest

    For permeability, you need a chloride dispensing agent that does not cause electrolyte imbalances. Linzess does, it also KILLED juvenile mice due to dehydration. Nice try though, although they are both chloride channel activators Amitiza is a much gentler agent. Also much cheaper for the patients and lots of clinical experience for the docs. 7 years, 7 million scripts.
     
  7. Anonymous

    Anonymous Guest

    I love how you emphasis Linzess KILLED mice and downplay how Actos KILLS human beings.
     
  8. Anonymous

    Anonymous Guest

    Fact: Linzess kills mice

    Accusation: Actos "causes" bladder cancer

    World of difference. Good luck proving the latter in court.
     
  9. Anonymous

    Anonymous Guest

    Bladder cancer: Preclinical and clinical trial data, and results from an observational study suggest an increased risk of bladder cancer in pioglitazone users. The observational data further suggest that the risk increases with duration of use. Do not use in patients with active bladder cancer. Use caution when using in patients with a prior history of bladder cancer.




    STRAIGHT FROM THE ACTOS PI. Somebody better call the FDA and ask them to get this "accusation" removed from the PI.
     
  10. Anonymous

    Anonymous Guest

    Linzess is not a "chloride channel activator." Keep saying it though. It really lends itself to your credibility!
     
  11. Anonymous

    Anonymous Guest

    Not an activator. A dispenser. The end result is the EXACT same as Amitiza. It works on the GCC to release CL- ions into the gut. That is the EXACT same thing Amitiza ends up doing. When that is stated to doctors, they nod and conclude "why would I want a patient to pay 3 times the co-pay for a me-too". There's the credibility for you.
     
  12. Anonymous

    Anonymous Guest

    As if restoring tight junctions means anything, clinically?! Maybe your friend will also give some Dexilant samples so you can take advantage of the "dual delayed release." Thankfully, most MD's are smart enough to recognize marketing BS when they hear it!
     
  13. Anonymous

    Anonymous Guest

    Not only chloride ions. Keep going, you're getting warmer....

    Oh yeah, your presentation concerning cost is factually inaccurate, as well. Don't worry, we love the look the MD's give us when we supply them with the correct info. Shall we say, enlightening?!
     
  14. Anonymous

    Anonymous Guest

    You seem like you think you are smart. Unfortunately, the cost is at MINIMUM twice as expensive (fact). Try reading your copay card or perusing a formulary once in a while. In contrast, I love the look on Drs faces when they are "enlightened" that Linzess has the same chem structure as diarrhea causing toxins . It explains what their patients who try Linzess are experiencing when they have unpleasant fiery explosions. I also like how when Linzess's BLACK BOX warning comes up, you just sidestep to unrelated products. Sad really. Maybe you should have been a personal injury lawyer. Run along back under your forest bridge.
     
  15. Anonymous

    Anonymous Guest

    Fact, the AWP for Linzess is $1 cheaper per day than Amitiza.

    Fact, most doctors don't treat mice.

    Fact, there is no clinical relevance to the restoration of tight junctions.

    Fact, your story about "fiery" explosions across different boards is stale, but keep bleeding NRx share while you get all moist over 7 years, 7 million prescriptions.
     
  16. Anonymous

    Anonymous Guest

    Fact. You are promoting that doctors use half the FDA approved dose of Linzess in order to minimize the severe diarrhea effects and asking them to wait 7 weeks for patients to realize the full effects of Linzess. That's off label!
     
  17. Anonymous

    Anonymous Guest

    Linzess is a peptide, there is no way to split the dose. FACT. So how is half the FDA approved dose being marketed when it is not biologically possible to do so?
     
  18. Anonymous

    Anonymous Guest

    Wow no wonder you've only gotten 7 million rxs in 7 years. Do your homework and stop listening to BS from corporate about the efficacy data for Linzess.

    And stop harping about 7 million rxs, you do know that 35 million people have CIC in the US right?
     
  19. Anonymous

    Anonymous Guest

    "Stop harping about 7 million rxs"?????? 7 million was only mentioned 3 times on this thread and you mentioned it twice. Loser.
     
  20. Anonymous

    Anonymous Guest

    Yup never heard Takeda trolls bragging about their 7 years, 7 million scripts story on these boards lol!
     

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