I took Chantix a year ago for 8 weeks (1 week prior to quitting, as they recommend, and 7 more weeks off cigs). I did stay off cigarettes for the 7 weeks, but I think that was will power, not the Chantix. I never, ever lost the urge to smoke, so the drug didn't have the desired effect. Quite the contrary, I was so flatulent as to be unemployable, and constantly nauseated. I even threw up in the only supermarket in town, which was fun for all. I didn't experience suicidal thoughts, but I did want to hurt myself. My arms were covered in deep scratches that brought blood, and I just withdrew from the world, couldn't talk to anybody. I've quit cold turkey twice before (as succesfully as Mark Twain, obv) and I lasted nine months each time. I never had the problems I've listed above when I went cold turkey. Well, the constant urge to smoke, of course. With all the restrictions and stigma associated with smoking, I can't imagine anyone who still wants to be a smoker. However, I think the brain is the least-understood body part by medical science. It certainly seems that medications that act on the brain have a small but significant chance of suicide that conveniently don't show up in clinical trials. I read somewhere that Chantix had NOT been tested on people who abuse alcohol. What sort of a trial is that? Ask any doctor, or anyone who owned a restaurant prior to the smoking bans, and they will tell you that heavy smokers are far more likely to be heavy drinkers than the average member of society. That's why most restaurant owners were so against the smoking ban: They make much more money on the alcohol than they do on food. The FDA needs to monitor this, although it is famously slow and reluctant to reverse approvals. I doubt coroners are going to list cause of death: chantix, when reviewing a suicide. It would be good if they all mentioned it and were informed of it by the survivors. First do no harm... Of course, that is not the pharmaceutical companies' oath. My sincere condolences to the posters on this site who have lost someone to suicide.