Charles Charles call of the morning. Yes Doctor, Brintellix is new to the market, How does it work? Well, lets see Lundbeck, the developer of Brintellix, it’s admitted that the cause of depression is unknown. Nonetheless, they cavalierly play with brain chemistry about which they know very little. Making this particular drug potentially even worse than any other SSRI is that it doesn’t limit itself to one or two pathways in the brain. It manipulates a total of 6 receptors! WOW, 6 receptors? Does anyone really know what the effects of this manipulation of neural transmission will be? hmmm.. lets see…The contribution of each of these activities to Brintellix’s antidepressant effect has not been established. It is considered to be the first and only compound with this combination of pharmacodynamic activity. The clinical relevance of this is unknown. 'Is it covered by insurance or medicare? Nope, maybe 4th tier that requires a documented step therapy. Then he shows me this list of prices of current treatments. Escitalopram 20mg $11.20 (Generic Lexapro) Citalopram 40mg $4.00 (Generic Celexa) Sertraline 100mg $8.94 (Generic Zoloft) Yes, but marketing tells me its "Different, and better"……. SNRI comparisons. So, he proceeds to ask me how Brintellix compares to other SSRIs? Well, the hyped studies that appear to demonstrate both efficacy and safety are far from the full story. In fact, some studies have shown no benefit over placebo whatsoever. Venlafaxine 75mg $39.30 (Generic Effexor) Duloxetine 60mg $130.88 (Generic Cymbalta) Viibryd - Forest's New and exciting SSRI $163.50 Then he tells me that Brintelllix 10mg is $235.36 for 30-days. I say, so you have looked it up? plus its flat priced with all doses…. He asked me if I watched the Super Bowl. I respond, yes, why? He then says that Brintellix is just like that Maserati commercial…. I'm thinking its a nice car, but 99% of Americans cannot afford it, but kudos' to the other 1% who enjoyed it. This is like your "Exciting New Drug"…… as he's walking off…. My response… So, does this mean you will try it? I can't wait to leave a success story voicemail that I actually saw a provider and had an in-depth educational conversation. On to the next call we go!