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<p>[QUOTE="Anonymous, post: 3814423"]Androgel: The #1 topical treatment for "low t". Currently promoted by both Abbott ans Solvay's Primary Care Sales forces.</p><p><br /></p><p><a href="http://www.pharmalot.com/2010/06/the-lowdown-on-low-testosterone-and-androgel/" target="_blank" class="externalLink ProxyLink" data-proxy-href="http://www.pharmalot.com/2010/06/the-lowdown-on-low-testosterone-and-androgel/" rel="nofollow">http://www.pharmalot.com/2010/06/the-lowdown-on-low-testosterone-and-androgel/</a></p><p><br /></p><p>The Lowdown On Low Testosterone And AndroGel </p><p>18 Comments </p><p>By Ed Silverman // June 23rd, 2010 // 9:10 am</p><p><br /></p><p>A new study that finds low testosterone is much less common in older men than previously thought - and is closely identified with just nine specific symptoms - may cause physicians and patients to rethink their use of various elixirs. Take AndroGel, for instance. The salve is cleverly promoted on an unbranded web site called ‘Is It Low T?,’ which features a quiz. The site lists various symptoms and risks purported to be associated with the condition, although some do not match what was noted in the study, which was published last week in The New England Journal of Medicine.</p><p><br /></p><p>The study found that only 2 percent of men aged 40 to 80 suffer from the condition, which is also called male menopause, andropause or late-onset hypogonadism. The researchers measured testosterone levels in 3,369 men between those ages and then correlated their levels with different symptoms. Of 32 possible symptoms, only nine were linked with decreased testosterone. Three were physical - unable to engage in strenuous activity, walk about a mile or to bend over or kneel - and three were psychological — low energy, sadness and fatigue. However, these six symptoms were only mildly linked to the problem, while three sexual symptoms - less frequent morning erections, low sex drive and erectile dysfunction - were closely related to low testosterone.</p><p><br /></p><p>“Our results also highlight the substantial overlap between late-onset hypogonadism and non-specific symptoms of aging. The application of these new criteria can guard against the excessive diagnosis of hypogonadism and curb the injudicious use of testosterone therapy in older men,” conclude the researchers, who noted the condition is usually associated with advancing age, yet there is little evidence about the “exact criteria for identifying testosterone deficiency in older men.”</p><p><br /></p><p>Meanwhile, Abbott’s Solvay Pharmaceuticals unit actively promotes on its site that low testosterone affects more than 13 million men in the US over the age of 45. An Abbott spokesman points to a pair of studies used to bolster the notion that low testosterone will increase substantially with age, including in men well past 65 years old, although these were published in 2004 and 2007 (look here and here). Yet the AndroGel prescribing info acknowledges there haven’t been enough men 65 and older who have participated in clinical trials to know whether the treatment is safe or effective. And it is now 2010. Of course, now that the NEJM study dismisses the notion that older men are more likely to develop the problem, Solvay may not have to conduct a study.</p><p><br /></p><p>The Low T site also states that the risk of developing low testosterone is 2.4 times greater if one is obese; 2.1 times greater if is one has diabetes; 1.8 greater with high blood pressure and a 1.5 higher risk if one also has high cholesterol. The evidence for this claim comes from this 2006 study. These may be accurate, although for the record, all five authors had ties to Solvay (click on authors and disclosures in the link to the study). Similarly, six of the seven authors of the Endocrine Society Clinical Guidelines for treating low testosterone have ties to Abbott (see page 31). This may confuse some people, since the ‘Low T’ site is identified as a Solvay site. However, a summary of the older version of the guidelines lists financial ties to Solvay (see this).</p><p><br /></p><p>Also interesting is the pop quiz….</p><p><br /></p><p><br /></p><p>To gauge its usefulness, we deliberately answered ‘no’ to each of the 10 questions, which asked about whether we had lost our libido, energy, strength, height, enjoyment of life, and a few other choice topics. In other words, we deliberately avoided offering any indication that a problem may exist. Just the same, we received this reply: “Your answers show that you have a lower risk for low testosterone (Low T). But it’s still important to talk with your doctor about your symptoms. They may be caused by treatable condition.” What symptoms? Hard to say. Unless one is being pushed to ask a doctor for something. </p><p><br /></p><p>In response to questions, the spokesman tells us that the site is “designed to simply raise awareness about the condition so that men who believe they’re suffering from the problem can have a conversation with their doctor about it…The quiz is not a diagnostic tool, but is a trigger to have that dialogue with the physician. Someone who takes the quiz may be feeling something isn’t right, so this says that perhaps they should still explore that. But it’s not intended to be diagnostic.”</p><p><br /></p><p>And what about the site? Will Solvay modify it to reflect the findings from the NEJM study? “We believe there’s plenty of data that would suggest there’s a constellation of symptoms that may be associated with Low T,” he says. “We certainly always encourage continued scientific discovery and continue to look at this, but we still feel sufficient data out there that suggests this whole array of symptoms maybe associated with Low T.”[/QUOTE]</p><p><br /></p>
[QUOTE="Anonymous, post: 3814423"]Androgel: The #1 topical treatment for "low t". Currently promoted by both Abbott ans Solvay's Primary Care Sales forces. [url]http://www.pharmalot.com/2010/06/the-lowdown-on-low-testosterone-and-androgel/[/url] The Lowdown On Low Testosterone And AndroGel 18 Comments By Ed Silverman // June 23rd, 2010 // 9:10 am A new study that finds low testosterone is much less common in older men than previously thought - and is closely identified with just nine specific symptoms - may cause physicians and patients to rethink their use of various elixirs. Take AndroGel, for instance. The salve is cleverly promoted on an unbranded web site called ‘Is It Low T?,’ which features a quiz. The site lists various symptoms and risks purported to be associated with the condition, although some do not match what was noted in the study, which was published last week in The New England Journal of Medicine. The study found that only 2 percent of men aged 40 to 80 suffer from the condition, which is also called male menopause, andropause or late-onset hypogonadism. The researchers measured testosterone levels in 3,369 men between those ages and then correlated their levels with different symptoms. Of 32 possible symptoms, only nine were linked with decreased testosterone. Three were physical - unable to engage in strenuous activity, walk about a mile or to bend over or kneel - and three were psychological — low energy, sadness and fatigue. However, these six symptoms were only mildly linked to the problem, while three sexual symptoms - less frequent morning erections, low sex drive and erectile dysfunction - were closely related to low testosterone. “Our results also highlight the substantial overlap between late-onset hypogonadism and non-specific symptoms of aging. The application of these new criteria can guard against the excessive diagnosis of hypogonadism and curb the injudicious use of testosterone therapy in older men,” conclude the researchers, who noted the condition is usually associated with advancing age, yet there is little evidence about the “exact criteria for identifying testosterone deficiency in older men.” Meanwhile, Abbott’s Solvay Pharmaceuticals unit actively promotes on its site that low testosterone affects more than 13 million men in the US over the age of 45. An Abbott spokesman points to a pair of studies used to bolster the notion that low testosterone will increase substantially with age, including in men well past 65 years old, although these were published in 2004 and 2007 (look here and here). Yet the AndroGel prescribing info acknowledges there haven’t been enough men 65 and older who have participated in clinical trials to know whether the treatment is safe or effective. And it is now 2010. Of course, now that the NEJM study dismisses the notion that older men are more likely to develop the problem, Solvay may not have to conduct a study. The Low T site also states that the risk of developing low testosterone is 2.4 times greater if one is obese; 2.1 times greater if is one has diabetes; 1.8 greater with high blood pressure and a 1.5 higher risk if one also has high cholesterol. The evidence for this claim comes from this 2006 study. These may be accurate, although for the record, all five authors had ties to Solvay (click on authors and disclosures in the link to the study). Similarly, six of the seven authors of the Endocrine Society Clinical Guidelines for treating low testosterone have ties to Abbott (see page 31). This may confuse some people, since the ‘Low T’ site is identified as a Solvay site. However, a summary of the older version of the guidelines lists financial ties to Solvay (see this). Also interesting is the pop quiz…. To gauge its usefulness, we deliberately answered ‘no’ to each of the 10 questions, which asked about whether we had lost our libido, energy, strength, height, enjoyment of life, and a few other choice topics. In other words, we deliberately avoided offering any indication that a problem may exist. Just the same, we received this reply: “Your answers show that you have a lower risk for low testosterone (Low T). But it’s still important to talk with your doctor about your symptoms. They may be caused by treatable condition.” What symptoms? Hard to say. Unless one is being pushed to ask a doctor for something. In response to questions, the spokesman tells us that the site is “designed to simply raise awareness about the condition so that men who believe they’re suffering from the problem can have a conversation with their doctor about it…The quiz is not a diagnostic tool, but is a trigger to have that dialogue with the physician. Someone who takes the quiz may be feeling something isn’t right, so this says that perhaps they should still explore that. But it’s not intended to be diagnostic.” And what about the site? Will Solvay modify it to reflect the findings from the NEJM study? “We believe there’s plenty of data that would suggest there’s a constellation of symptoms that may be associated with Low T,” he says. “We certainly always encourage continued scientific discovery and continue to look at this, but we still feel sufficient data out there that suggests this whole array of symptoms maybe associated with Low T.”[/QUOTE]
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Cafepharma Message Boards | Pharma Sales, Device Sales, Lab Sales
Home
Forums
>
Pharma/Biotech Companies
>
Eli Lilly
>
Axiron
>
Cafepharma Message Boards | Pharma Sales, Device Sales, Lab Sales
Home
Forums
>
Pharma/Biotech Companies
>
Eli Lilly
>
Axiron
>